Title |
DPP6 Loss Impacts Hippocampal Synaptic Development and Induces Behavioral Impairments in Recognition, Learning and Memory
|
---|---|
Published in |
Frontiers in Cellular Neuroscience, March 2018
|
DOI | 10.3389/fncel.2018.00084 |
Pubmed ID | |
Authors |
Lin Lin, Jonathan G. Murphy, Rose-Marie Karlsson, Ronald S. Petralia, Jakob J. Gutzmann, Daniel Abebe, Ya-Xian Wang, Heather A. Cameron, Dax A. Hoffman |
Abstract |
DPP6 is well known as an auxiliary subunit of Kv4-containing, A-type K+ channels which regulate dendritic excitability in hippocampal CA1 pyramidal neurons. We have recently reported, however, a novel role for DPP6 in regulating dendritic filopodia formation and stability, affecting synaptic development and function. These results are notable considering recent clinical findings associating DPP6 with neurodevelopmental and intellectual disorders. Here we assessed the behavioral consequences of DPP6 loss. We found that DPP6 knockout (DPP6-KO) mice are impaired in hippocampus-dependent learning and memory. Results from the Morris water maze and T-maze tasks showed that DPP6-KO mice exhibit slower learning and reduced memory performance. DPP6 mouse brain weight is reduced throughout development compared with WT, and in vitro imaging results indicated that DPP6 loss affects synaptic structure and motility. Taken together, these results show impaired synaptic development along with spatial learning and memory deficiencies in DPP6-KO mice. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
Switzerland | 1 | 25% |
Brazil | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 13% |
Student > Ph. D. Student | 4 | 13% |
Student > Doctoral Student | 3 | 10% |
Other | 2 | 7% |
Student > Bachelor | 2 | 7% |
Other | 6 | 20% |
Unknown | 9 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 7 | 23% |
Agricultural and Biological Sciences | 3 | 10% |
Psychology | 3 | 10% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Medicine and Dentistry | 2 | 7% |
Other | 3 | 10% |
Unknown | 10 | 33% |