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Attention Score in Context
| Title |
Type 2 Diabetes Leads to Axon Initial Segment Shortening in db/db Mice
|
|---|---|
| Published in |
Frontiers in Cellular Neuroscience, June 2018
|
| DOI | 10.3389/fncel.2018.00146 |
| Pubmed ID | |
| Authors |
Leonid M. Yermakov, Domenica E. Drouet, Ryan B. Griggs, Khalid M. Elased, Keiichiro Susuki |
| Abstract |
Cognitive and mood impairments are common central nervous system complications of type 2 diabetes, although the neuronal mechanism(s) remains elusive. Previous studies focused mainly on neuronal inputs such as altered synaptic plasticity. Axon initial segment (AIS) is a specialized functional domain within neurons that regulates neuronal outputs. Structural changes of AIS have been implicated as a key pathophysiological event in various psychiatric and neurological disorders. Here we evaluated the structural integrity of the AIS in brains of db/db mice, an established animal model of type 2 diabetes associated with cognitive and mood impairments. We assessed the AIS before (5 weeks of age) and after (10 weeks) the development of type 2 diabetes, and after daily exercise treatment of diabetic condition. We found that the development of type 2 diabetes is associated with significant AIS shortening in both medial prefrontal cortex and hippocampus, as evident by immunostaining of the AIS structural protein βIV spectrin. AIS shortening occurs in the absence of altered neuronal and AIS protein levels. We found no change in nodes of Ranvier, another neuronal functional domain sharing a molecular organization similar to the AIS. This is the first study to identify AIS alteration in type 2 diabetes condition. Since AIS shortening is known to lower neuronal excitability, our results may provide a new avenue for understanding and treating cognitive and mood impairments in type 2 diabetes. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 43 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 21% |
| Student > Master | 6 | 14% |
| Researcher | 4 | 9% |
| Student > Postgraduate | 3 | 7% |
| Student > Bachelor | 2 | 5% |
| Other | 7 | 16% |
| Unknown | 12 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 10 | 23% |
| Agricultural and Biological Sciences | 4 | 9% |
| Biochemistry, Genetics and Molecular Biology | 3 | 7% |
| Medicine and Dentistry | 3 | 7% |
| Nursing and Health Professions | 2 | 5% |
| Other | 6 | 14% |
| Unknown | 15 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 June 2018.
All research outputs
#20,522,137
of 23,090,520 outputs
Outputs from Frontiers in Cellular Neuroscience
#3,600
of 4,278 outputs
Outputs of similar age
#288,643
of 328,957 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#90
of 102 outputs
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So far Altmetric has tracked 4,278 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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