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The Role of the Microtubule Cytoskeleton in Neurodevelopmental Disorders

Overview of attention for article published in Frontiers in Cellular Neuroscience, June 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (52nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (61st percentile)

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288 Mendeley
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Title
The Role of the Microtubule Cytoskeleton in Neurodevelopmental Disorders
Published in
Frontiers in Cellular Neuroscience, June 2018
DOI 10.3389/fncel.2018.00165
Pubmed ID
Authors

Micaela Lasser, Jessica Tiber, Laura Anne Lowery

Abstract

Neurons depend on the highly dynamic microtubule (MT) cytoskeleton for many different processes during early embryonic development including cell division and migration, intracellular trafficking and signal transduction, as well as proper axon guidance and synapse formation. The coordination and support from MTs is crucial for newly formed neurons to migrate appropriately in order to establish neural connections. Once connections are made, MTs provide structural integrity and support to maintain neural connectivity throughout development. Abnormalities in neural migration and connectivity due to genetic mutations of MT-associated proteins can lead to detrimental developmental defects. Growing evidence suggests that these mutations are associated with many different neurodevelopmental disorders, including intellectual disabilities (ID) and autism spectrum disorders (ASD). In this review article, we highlight the crucial role of the MT cytoskeleton in the context of neurodevelopment and summarize genetic mutations of various MT related proteins that may underlie or contribute to neurodevelopmental disorders.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 288 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 288 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 50 17%
Student > Bachelor 42 15%
Student > Master 36 13%
Researcher 30 10%
Student > Doctoral Student 21 7%
Other 15 5%
Unknown 94 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 75 26%
Neuroscience 52 18%
Agricultural and Biological Sciences 29 10%
Medicine and Dentistry 8 3%
Psychology 6 2%
Other 21 7%
Unknown 97 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2018.
All research outputs
#12,907,095
of 23,092,602 outputs
Outputs from Frontiers in Cellular Neuroscience
#1,561
of 4,279 outputs
Outputs of similar age
#154,374
of 328,569 outputs
Outputs of similar age from Frontiers in Cellular Neuroscience
#37
of 101 outputs
Altmetric has tracked 23,092,602 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,279 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,569 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 101 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.