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Attention Score in Context
| Title |
Closing the loop in primate prefrontal cortex: inter-laminar processing
|
|---|---|
| Published in |
Frontiers in Neural Circuits, January 2012
|
| DOI | 10.3389/fncir.2012.00088 |
| Pubmed ID | |
| Authors |
Ioan Opris, Joshua L. Fuqua, Peter F. Huettl, Greg A. Gerhardt, Theodore W. Berger, Robert E. Hampson, Sam A. Deadwyler |
| Abstract |
Prefrontal cortical (PFC) activity in the primate brain emerging from minicolumnar microcircuits plays a critical role in cognitive processes dealing with executive control of behavior. However, the specific operations of columnar laminar processing in prefrontal cortex (PFC) are not completely understood. Here we show via implementation of unique microanatomical recording and stimulating arrays, that minicolumns in PFC are involved in the executive control of behavior in rhesus macaque nonhuman primates (NHPs) performing a delayed-match-to-sample (DMS) task. PFC neurons demonstrate functional interactions between pairs of putative pyramidal cells within specified cortical layers via anatomically oriented minicolumns. Results reveal target-specific, spatially tuned firing between inter-laminar (layer 2/3 and layer 5) pairs of neurons participating in the gating of information during the decision making phase of the task with differential correlations between activity in layer 2/3 and layer 5 in the integration of spatial vs. object-specific information for correct task performance. Such inter-laminar processing was exploited by the interfacing of an online model which delivered stimulation to layer 5 locations in a pattern associated with successful performance thereby closing the columnar loop externally in a manner that mimicked normal processing in the same task. These unique technologies demonstrate that PFC neurons encode and process information via minicolumns which provides a closed loop form of "executive function," hence disruption of such inter-laminar processing could form the bases for cognitive dysfunction in primate brain. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 4% |
| Canada | 1 | 1% |
| Netherlands | 1 | 1% |
| Japan | 1 | 1% |
| Belarus | 1 | 1% |
| Unknown | 86 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 28 | 30% |
| Student > Ph. D. Student | 21 | 22% |
| Student > Master | 8 | 9% |
| Professor > Associate Professor | 7 | 7% |
| Student > Bachelor | 6 | 6% |
| Other | 12 | 13% |
| Unknown | 12 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 25 | 27% |
| Neuroscience | 15 | 16% |
| Engineering | 11 | 12% |
| Psychology | 10 | 11% |
| Medicine and Dentistry | 4 | 4% |
| Other | 12 | 13% |
| Unknown | 17 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 November 2012.
All research outputs
#20,174,175
of 22,687,320 outputs
Outputs from Frontiers in Neural Circuits
#1,026
of 1,209 outputs
Outputs of similar age
#221,211
of 244,125 outputs
Outputs of similar age from Frontiers in Neural Circuits
#44
of 73 outputs
Altmetric has tracked 22,687,320 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,209 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,125 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 73 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.