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Cholinergic modulation of the medial prefrontal cortex: the role of nicotinic receptors in attention and regulation of neuronal activity

Overview of attention for article published in Frontiers in Neural Circuits, March 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • Good Attention Score compared to outputs of the same age and source (68th percentile)

Mentioned by

blogs
1 blog
googleplus
1 Google+ user

Readers on

mendeley
283 Mendeley
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Title
Cholinergic modulation of the medial prefrontal cortex: the role of nicotinic receptors in attention and regulation of neuronal activity
Published in
Frontiers in Neural Circuits, March 2014
DOI 10.3389/fncir.2014.00017
Pubmed ID
Authors

Bernard Bloem, Rogier B. Poorthuis, Huibert D. Mansvelder

Abstract

Acetylcholine (ACh) release in the medial prefrontal cortex (mPFC) is crucial for normal cognitive performance. Despite the fact that many have studied how ACh affects neuronal processing in the mPFC and thereby influences attention behavior, there is still a lot unknown about how this occurs. Here we will review the evidence that cholinergic modulation of the mPFC plays a role in attention and we will summarize the current knowledge about the role between ACh receptors (AChRs) and behavior and how ACh receptor activation changes processing in the cortical microcircuitry. Recent evidence implicates fast phasic release of ACh in cue detection and attention. This review will focus mainly on the fast ionotropic nicotinic receptors and less on the metabotropic muscarinic receptors. Finally, we will review limitations of the existing studies and address how innovative technologies might push the field forward in order to gain understanding into the relation between ACh, neuronal activity and behavior.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 283 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 1%
Netherlands 1 <1%
Canada 1 <1%
United Kingdom 1 <1%
Japan 1 <1%
Mexico 1 <1%
Unknown 275 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 80 28%
Researcher 40 14%
Student > Master 35 12%
Student > Bachelor 26 9%
Student > Postgraduate 16 6%
Other 45 16%
Unknown 41 14%
Readers by discipline Count As %
Neuroscience 84 30%
Agricultural and Biological Sciences 67 24%
Medicine and Dentistry 20 7%
Psychology 19 7%
Biochemistry, Genetics and Molecular Biology 7 2%
Other 31 11%
Unknown 55 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2015.
All research outputs
#4,480,624
of 22,757,090 outputs
Outputs from Frontiers in Neural Circuits
#273
of 1,213 outputs
Outputs of similar age
#44,487
of 220,834 outputs
Outputs of similar age from Frontiers in Neural Circuits
#5
of 16 outputs
Altmetric has tracked 22,757,090 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,213 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 220,834 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.