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The piriform, perirhinal, and entorhinal cortex in seizure generation

Overview of attention for article published in Frontiers in Neural Circuits, May 2015
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1 X user

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Title
The piriform, perirhinal, and entorhinal cortex in seizure generation
Published in
Frontiers in Neural Circuits, May 2015
DOI 10.3389/fncir.2015.00027
Pubmed ID
Authors

Marta S. Vismer, Patrick A. Forcelli, Mark D. Skopin, Karen Gale, Mohamad Z. Koubeissi

Abstract

Understanding neural network behavior is essential to shed light on epileptogenesis and seizure propagation. The interconnectivity and plasticity of mammalian limbic and neocortical brain regions provide the substrate for the hypersynchrony and hyperexcitability associated with seizure activity. Recurrent unprovoked seizures are the hallmark of epilepsy, and limbic epilepsy is the most common type of medically-intractable focal epilepsy in adolescents and adults that necessitates surgical evaluation. In this review, we describe the role and relationships among the piriform (PIRC), perirhinal (PRC), and entorhinal cortex (ERC) in seizure-generation and epilepsy. The inherent function, anatomy, and histological composition of these cortical regions are discussed. In addition, the neurotransmitters, intrinsic and extrinsic connections, and the interaction of these regions are described. Furthermore, we provide evidence based on clinical research and animal models that suggest that these cortical regions may act as key seizure-trigger zones and, even, epileptogenesis.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 194 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 2%
United States 2 1%
Netherlands 1 <1%
Brazil 1 <1%
Germany 1 <1%
Unknown 186 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 31 16%
Researcher 26 13%
Student > Master 20 10%
Student > Doctoral Student 16 8%
Student > Bachelor 14 7%
Other 42 22%
Unknown 45 23%
Readers by discipline Count As %
Neuroscience 54 28%
Medicine and Dentistry 31 16%
Agricultural and Biological Sciences 21 11%
Biochemistry, Genetics and Molecular Biology 6 3%
Engineering 5 3%
Other 24 12%
Unknown 53 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 May 2015.
All research outputs
#15,813,904
of 23,577,654 outputs
Outputs from Frontiers in Neural Circuits
#785
of 1,243 outputs
Outputs of similar age
#157,353
of 267,178 outputs
Outputs of similar age from Frontiers in Neural Circuits
#13
of 19 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,243 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,178 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.