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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Transcranial Magnetic Stimulation of Human Adult Stem Cells in the Mammalian Brain
|
|---|---|
| Published in |
Frontiers in Neural Circuits, March 2016
|
| DOI | 10.3389/fncir.2016.00017 |
| Pubmed ID | |
| Authors |
Karlea L. Kremer, Ashleigh E. Smith, Lauren Sandeman, Joshua M. Inglis, Michael C. Ridding, Simon A. Koblar |
| Abstract |
The burden of stroke on the community is growing, and therefore, so is the need for a therapy to overcome the disability following stroke. Cellular-based therapies are being actively investigated at a pre-clinical and clinical level. Studies have reported the beneficial effects of exogenous stem cell implantation, however, these benefits are also associated with limited survival of implanted stem cells. This exploratory study investigated the use of transcranial magnetic stimulation (TMS) as a complementary therapy to increase stem cell survival following implantation of human dental pulp stem cells (DPSC) in the rodent cortex. Sprague-Dawley rats were anesthetized and injected with 6 × 10(5) DPSC or control media via an intracranial injection, and then received real TMS (TMS0.2 Hz) or sham TMS (TMSsham) every 2nd day beginning on day 3 post DPSC injection for 2 weeks. Brain sections were analyzed for the survival, migration and differentiation characteristics of the implanted cells. In animals treated with DPSC and TMS0.2 Hz there were significantly less implanted DPSC and those that survived remained in the original cerebral hemisphere compared to animals that received TMSsham. The surviving implanted DPSC in TMS0.2 Hz were also found to express the apoptotic marker Caspase-3. We suggest that TMS at this intensity may cause an increase in glutamate levels, which promotes an unfavorable environment for stem cell implantation, proliferation and differentiation. It should be noted that only one paradigm of TMS was tested as this was conducted as a exploratory study, and further TMS paradigms should be investigated in the future. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 25% |
| Switzerland | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 2% |
| Canada | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 39 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 14% |
| Student > Bachelor | 5 | 12% |
| Student > Ph. D. Student | 5 | 12% |
| Student > Master | 4 | 10% |
| Student > Postgraduate | 3 | 7% |
| Other | 5 | 12% |
| Unknown | 14 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 12 | 29% |
| Medicine and Dentistry | 6 | 14% |
| Nursing and Health Professions | 4 | 10% |
| Immunology and Microbiology | 1 | 2% |
| Veterinary Science and Veterinary Medicine | 1 | 2% |
| Other | 3 | 7% |
| Unknown | 15 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 March 2016.
All research outputs
#12,888,808
of 22,856,968 outputs
Outputs from Frontiers in Neural Circuits
#515
of 1,217 outputs
Outputs of similar age
#147,451
of 326,713 outputs
Outputs of similar age from Frontiers in Neural Circuits
#18
of 33 outputs
Altmetric has tracked 22,856,968 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,217 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 326,713 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.