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Role of the Orexin System on the Hypothalamus-Pituitary-Thyroid Axis

Overview of attention for article published in Frontiers in Neural Circuits, August 2016
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Title
Role of the Orexin System on the Hypothalamus-Pituitary-Thyroid Axis
Published in
Frontiers in Neural Circuits, August 2016
DOI 10.3389/fncir.2016.00066
Pubmed ID
Authors

Antonietta Messina, Carolina De Fusco, Vincenzo Monda, Maria Esposito, Fiorenzo Moscatelli, Anna Valenzano, Marco Carotenuto, Emanuela Viggiano, Sergio Chieffi, Vincenzo De Luca, Giuseppe Cibelli, Marcellino Monda, Giovanni Messina

Abstract

Hypocretin/orexin (ORX) are two hypothalamic neuropeptides discovered in 1998. Since their discovery, they have been one of the most studied neuropeptide systems because of their projecting fields innervating various brain areas. The orexinergic system is tied to sleep-wakefulness cycle, and narcolepsy is a consequence of their system hypofunction. Orexinergic system is also involved in many other autonomic functions such as feeding, thermoregulation, cardiovascular and neuroendocrine regulation. The main aim of this mini review article is to investigate the relationship between ORX and thyroid system regulation. Although knowledge about the ORX system is evolving, its putative effects on hypothalamic-pituitary-thyroid (HPT) axis still appear unclear. We analyzed some studies about ORX control of HPT axis to know better the relationship between them. The studies that were analyzed suggest Hypocretin/ORX to modulate the thyroid regulation, but the nature (excitatory or inhibitory) of this possible interaction remains actually unclear and needs to be confirmed.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 2%
Italy 1 2%
Unknown 64 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 11%
Student > Master 7 11%
Student > Bachelor 7 11%
Student > Doctoral Student 6 9%
Professor > Associate Professor 6 9%
Other 13 20%
Unknown 20 30%
Readers by discipline Count As %
Neuroscience 12 18%
Medicine and Dentistry 11 17%
Agricultural and Biological Sciences 7 11%
Biochemistry, Genetics and Molecular Biology 5 8%
Nursing and Health Professions 2 3%
Other 6 9%
Unknown 23 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2017.
All research outputs
#14,294,710
of 24,401,594 outputs
Outputs from Frontiers in Neural Circuits
#575
of 1,270 outputs
Outputs of similar age
#184,578
of 346,508 outputs
Outputs of similar age from Frontiers in Neural Circuits
#13
of 31 outputs
Altmetric has tracked 24,401,594 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,270 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 346,508 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.