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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Eye-Drops for Activation of DREADDs
|
|---|---|
| Published in |
Frontiers in Neural Circuits, November 2017
|
| DOI | 10.3389/fncir.2017.00093 |
| Pubmed ID | |
| Authors |
William T. Keenan, Diego C. Fernandez, Lukas J. Shumway, Haiqing Zhao, Samer Hattar |
| Abstract |
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are an important tool for modulating and understanding neural circuits. Depending on the DREADD system used, DREADD-targeted neurons can be activated or repressed in vivo following a dose of the DREADD agonist clozapine-N-oxide (CNO). Because DREADD experiments often involve behavioral assays, the method of CNO delivery is important. Currently, the most common delivery method is intraperitoneal (IP) injection. IP injection is both a fast and reliable technique, but it is painful and stressful particularly when many injections are required. We sought an alternative CNO delivery paradigm, which would retain the speed and reliability of IP injections without being as invasive. Here, we show that CNO can be effectively delivered topically via eye-drops. Eye-drops robustly activated DREADD-expressing neurons in the brain and peripheral tissues and does so at the same dosages as IP injection. Eye-drops provide an easier, less invasive and less stressful method for activating DREADDs in vivo. |
X Demographics
The data shown below were collected from the profiles of 79 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 34 | 43% |
| Canada | 4 | 5% |
| United Kingdom | 4 | 5% |
| France | 2 | 3% |
| China | 1 | 1% |
| India | 1 | 1% |
| Australia | 1 | 1% |
| Norway | 1 | 1% |
| Germany | 1 | 1% |
| Other | 5 | 6% |
| Unknown | 25 | 32% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 48 | 61% |
| Scientists | 25 | 32% |
| Science communicators (journalists, bloggers, editors) | 5 | 6% |
| Practitioners (doctors, other healthcare professionals) | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 117 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 23 | 20% |
| Student > Ph. D. Student | 21 | 18% |
| Student > Master | 13 | 11% |
| Student > Bachelor | 10 | 9% |
| Student > Postgraduate | 6 | 5% |
| Other | 19 | 16% |
| Unknown | 25 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 48 | 41% |
| Agricultural and Biological Sciences | 14 | 12% |
| Medicine and Dentistry | 10 | 9% |
| Biochemistry, Genetics and Molecular Biology | 9 | 8% |
| Psychology | 3 | 3% |
| Other | 3 | 3% |
| Unknown | 30 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 43. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 December 2017.
All research outputs
#959,381
of 25,263,619 outputs
Outputs from Frontiers in Neural Circuits
#22
of 1,298 outputs
Outputs of similar age
#21,617
of 451,302 outputs
Outputs of similar age from Frontiers in Neural Circuits
#3
of 39 outputs
Altmetric has tracked 25,263,619 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,298 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 451,302 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.