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Attention Score in Context
| Title |
A Versatile Method for Viral Transfection of Calcium Indicators in the Neonatal Mouse Brain
|
|---|---|
| Published in |
Frontiers in Neural Circuits, July 2018
|
| DOI | 10.3389/fncir.2018.00056 |
| Pubmed ID | |
| Authors |
Cynthia X. He, Erica D. Arroyo, Daniel A. Cantu, Anubhuti Goel, Carlos Portera-Cailliau |
| Abstract |
The first three postnatal weeks in rodents are a time when sensory experience drives the maturation of brain circuits, an important process that is not yet well understood. Alterations in this critical period of experience-dependent circuit assembly and plasticity contribute to several neurodevelopmental disorders, such as autism, epilepsy, and schizophrenia. Therefore, techniques for recording network activity and tracing neuronal connectivity over this time period are necessary for delineating circuit refinement in typical development and how it deviates in disease. Calcium imaging with GCaMP6 and other genetically encoded indicators is rapidly becoming the preferred method for recording network activity at the single-synapse and single-cell level in vivo, especially in genetically identified neuronal populations. We describe a protocol for intracortical injection of recombinant adeno-associated viruses in P1 neonatal mice and demonstrate its use for longitudinal imaging of GCaMP6s in the same neurons over several weeks to characterize the developmental desynchronization of cortical network activity. Our approach is ideally suited for chronic in vivo two-photon calcium imaging of neuronal activity from synapses to entire networks during the early postnatal period. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 20% |
| Germany | 1 | 20% |
| United States | 1 | 20% |
| Switzerland | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 90 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 24% |
| Student > Ph. D. Student | 17 | 19% |
| Student > Bachelor | 9 | 10% |
| Student > Master | 8 | 9% |
| Student > Postgraduate | 5 | 6% |
| Other | 12 | 13% |
| Unknown | 17 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 34 | 38% |
| Medicine and Dentistry | 12 | 13% |
| Agricultural and Biological Sciences | 9 | 10% |
| Biochemistry, Genetics and Molecular Biology | 7 | 8% |
| Immunology and Microbiology | 3 | 3% |
| Other | 7 | 8% |
| Unknown | 18 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2018.
All research outputs
#13,269,322
of 23,098,660 outputs
Outputs from Frontiers in Neural Circuits
#543
of 1,222 outputs
Outputs of similar age
#162,009
of 329,730 outputs
Outputs of similar age from Frontiers in Neural Circuits
#14
of 27 outputs
Altmetric has tracked 23,098,660 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,222 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,730 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.