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Direct Glutamatergic Signaling From Midbrain Dopaminergic Neurons Onto Pyramidal Prefrontal Cortex Neurons

Overview of attention for article published in Frontiers in Neural Circuits, August 2018
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Title
Direct Glutamatergic Signaling From Midbrain Dopaminergic Neurons Onto Pyramidal Prefrontal Cortex Neurons
Published in
Frontiers in Neural Circuits, August 2018
DOI 10.3389/fncir.2018.00070
Pubmed ID
Authors

José Luis Pérez-López, Rubén Contreras-López, Josué O. Ramírez-Jarquín, Fatuel Tecuapetla

Abstract

The dopaminergic neurons of the ventral tegmental area (VTA) have been identified with the ability to co-release dopamine and glutamate. This ability was first documented in the nucleus accumbens but showed to be absent in the dorsal striatum. Recently the ability to release glutamate from a subpopulation of the VTA dopaminergic neurons has been shown to control the prefrontal cortex (PFC) excitation through the exclusive innervation of GABAergic fast spiking interneurons. Here, using an optogenetic approach, we expand this view by presenting that the VTA dopaminergic neurons do not only innervate interneurons but also pyramidal PFC neurons. This finding opens the range of possibilities for the VTA dopaminergic neurons to modulate the activity of PFC.

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The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 60 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 32%
Researcher 12 20%
Student > Bachelor 9 15%
Student > Master 9 15%
Professor 2 3%
Other 4 7%
Unknown 5 8%
Readers by discipline Count As %
Neuroscience 32 53%
Agricultural and Biological Sciences 8 13%
Medicine and Dentistry 4 7%
Biochemistry, Genetics and Molecular Biology 3 5%
Chemistry 2 3%
Other 3 5%
Unknown 8 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2020.
All research outputs
#14,140,033
of 23,103,436 outputs
Outputs from Frontiers in Neural Circuits
#619
of 1,222 outputs
Outputs of similar age
#181,362
of 335,220 outputs
Outputs of similar age from Frontiers in Neural Circuits
#18
of 30 outputs
Altmetric has tracked 23,103,436 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,222 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,220 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.