Title |
Identifying endophenotypes of autism: a multivariate approach
|
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Published in |
Frontiers in Computational Neuroscience, June 2014
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DOI | 10.3389/fncom.2014.00060 |
Pubmed ID | |
Authors |
Fermín Segovia, Rosemary Holt, Michael Spencer, Juan M. Górriz, Javier Ramírez, Carlos G. Puntonet, Christophe Phillips, Lindsay Chura, Simon Baron-Cohen, John Suckling |
Abstract |
The existence of an endophenotype of autism spectrum condition (ASC) has been recently suggested by several commentators. It can be estimated by finding differences between controls and people with ASC that are also present when comparing controls and the unaffected siblings of ASC individuals. In this work, we used a multivariate methodology applied on magnetic resonance images to look for such differences. The proposed procedure consists of combining a searchlight approach and a support vector machine classifier to identify the differences between three groups of participants in pairwise comparisons: controls, people with ASC and their unaffected siblings. Then we compared those differences selecting spatially collocated as candidate endophenotypes of ASC. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 3 | 75% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 2% |
Japan | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 89 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 20 | 22% |
Student > Ph. D. Student | 19 | 20% |
Student > Bachelor | 13 | 14% |
Student > Master | 11 | 12% |
Professor > Associate Professor | 6 | 6% |
Other | 15 | 16% |
Unknown | 9 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 22 | 24% |
Neuroscience | 20 | 22% |
Agricultural and Biological Sciences | 8 | 9% |
Medicine and Dentistry | 7 | 8% |
Computer Science | 5 | 5% |
Other | 14 | 15% |
Unknown | 17 | 18% |