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Optimal number of stimulation contacts for coordinated reset neuromodulation

Overview of attention for article published in Frontiers in Neuroengineering, January 2013
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Title
Optimal number of stimulation contacts for coordinated reset neuromodulation
Published in
Frontiers in Neuroengineering, January 2013
DOI 10.3389/fneng.2013.00005
Pubmed ID
Authors

Borys Lysyansky, Oleksandr V. Popovych, Peter A. Tass

Abstract

In this computational study we investigate coordinated reset (CR) neuromodulation designed for an effective control of synchronization by multi-site stimulation of neuronal target populations. This method was suggested to effectively counteract pathological neuronal synchrony characteristic for several neurological disorders. We study how many stimulation sites are required for optimal CR-induced desynchronization. We found that a moderate increase of the number of stimulation sites may significantly prolong the post-stimulation desynchronized transient after the stimulation is completely switched off. This can, in turn, reduce the amount of the administered stimulation current for the intermittent ON-OFF CR stimulation protocol, where time intervals with stimulation ON are recurrently followed by time intervals with stimulation OFF. In addition, we found that the optimal number of stimulation sites essentially depends on how strongly the administered current decays within the neuronal tissue with increasing distance from the stimulation site. In particular, for a broad spatial stimulation profile, i.e., for a weak spatial decay rate of the stimulation current, CR stimulation can optimally be delivered via a small number of stimulation sites. Our findings may contribute to an optimization of therapeutic applications of CR neuromodulation.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 5%
Unknown 21 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 23%
Student > Bachelor 4 18%
Student > Ph. D. Student 4 18%
Student > Doctoral Student 2 9%
Professor 2 9%
Other 3 14%
Unknown 2 9%
Readers by discipline Count As %
Engineering 6 27%
Agricultural and Biological Sciences 3 14%
Neuroscience 3 14%
Computer Science 2 9%
Psychology 2 9%
Other 5 23%
Unknown 1 5%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2013.
All research outputs
#20,196,270
of 22,714,025 outputs
Outputs from Frontiers in Neuroengineering
#70
of 82 outputs
Outputs of similar age
#248,772
of 280,752 outputs
Outputs of similar age from Frontiers in Neuroengineering
#7
of 9 outputs
Altmetric has tracked 22,714,025 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 82 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,752 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.