Title |
The Promise of Neuroprotective Agents in Parkinson’s Disease
|
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Published in |
Frontiers in Neurology, January 2011
|
DOI | 10.3389/fneur.2011.00068 |
Pubmed ID | |
Authors |
Stacey E. Seidl, Judith A. Potashkin |
Abstract |
Parkinson's disease (PD) is characterized by loss of dopamine neurons in the substantia nigra of the brain. Since there are limited treatment options for PD, neuroprotective agents are currently being tested as a means to slow disease progression. Agents targeting oxidative stress, mitochondrial dysfunction, and inflammation are prime candidates for neuroprotection. This review identifies Rasagiline, Minocycline, and creatine, as the most promising neuroprotective agents for PD, and they are all currently in phase III trials. Other agents possessing protective characteristics in delaying PD include stimulants, vitamins, supplements, and other drugs. Additionally, combination therapies also show benefits in slowing PD progression. The identification of neuroprotective agents for PD provides us with therapeutic opportunities for modifying the course of disease progression and, perhaps, reducing the risk of onset when preclinical biomarkers become available. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | <1% |
Australia | 1 | <1% |
Brazil | 1 | <1% |
Israel | 1 | <1% |
India | 1 | <1% |
Peru | 1 | <1% |
Mexico | 1 | <1% |
United States | 1 | <1% |
Unknown | 152 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 28 | 18% |
Student > Master | 24 | 15% |
Student > Bachelor | 18 | 11% |
Researcher | 13 | 8% |
Student > Postgraduate | 12 | 8% |
Other | 32 | 20% |
Unknown | 33 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 42 | 26% |
Medicine and Dentistry | 28 | 18% |
Neuroscience | 14 | 9% |
Biochemistry, Genetics and Molecular Biology | 9 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 4% |
Other | 25 | 16% |
Unknown | 35 | 22% |