Title |
Cognitive Dysfunction in Multiple Sclerosis
|
---|---|
Published in |
Frontiers in Neurology, January 2012
|
DOI | 10.3389/fneur.2012.00074 |
Pubmed ID | |
Authors |
Joana Guimarães, Maria José Sá |
Abstract |
In Multiple Sclerosis (MS) prevalence studies of community and clinical samples, indicate that 45-60% of patients are cognitively impaired. These cognitive dysfunctions have been traditionally described as heterogeneous, but more recent studies suggest that there is a specific pattern of MS-related cognitive dysfunctions. With the advent of disease-modifying medications for MS and emphasis on early intervention and treatment, detection of cognitive impairment at its earliest stage becomes particularly important. In this review the authors address: the cognitive domains most commonly impaired in MS (memory, attention, executive functions, speed of information processing, and visual-spatial abilities); the pathophysiological mechanism implied in MS cognitive dysfunction and correlated brain MRI features; the importance of neuropsychological assessment of MS patients in different stages of the disease and the influence of its course on cognitive performance; the most used tests and batteries for neuropsychological assessment; therapeutic strategies to improve cognitive abilities. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | <1% |
Portugal | 1 | <1% |
Colombia | 1 | <1% |
Australia | 1 | <1% |
Netherlands | 1 | <1% |
United Kingdom | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 228 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 38 | 16% |
Student > Bachelor | 36 | 15% |
Student > Ph. D. Student | 32 | 14% |
Researcher | 25 | 11% |
Student > Doctoral Student | 22 | 9% |
Other | 35 | 15% |
Unknown | 48 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 58 | 25% |
Medicine and Dentistry | 41 | 17% |
Neuroscience | 36 | 15% |
Agricultural and Biological Sciences | 9 | 4% |
Nursing and Health Professions | 8 | 3% |
Other | 24 | 10% |
Unknown | 60 | 25% |