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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection
|
|---|---|
| Published in |
Frontiers in Neurology, January 2013
|
| DOI | 10.3389/fneur.2013.00038 |
| Pubmed ID | |
| Authors |
Jean-François Trempe, Edward A. Fon |
| Abstract |
Autosomal recessive forms of Parkinson's disease are caused by mutations in three genes: Parkin, PINK1, and DJ-1. These genes encode for proteins with distinct enzymatic activities that may work together to confer neuroprotection. Parkin is an E3 ubiquitin ligase that has been shown to ubiquitinate substrates and to trigger proteasome-dependent degradation or autophagy, two crucial homeostatic processes in neurons. PINK1 is a mitochondrial protein kinase whose activity is required for Parkin-dependent mitophagy, a process that has been linked to neurodegeneration. Finally, DJ-1 is a protein homologous to a broad class of bacterial enzymes that may function as a sensor and modulator of reactive oxygen species, which have been implicated in neurodegenerative diseases. Here, we review the literature on the structure and biochemical functions of these three proteins. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 33% |
| United States | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 215 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | <1% |
| United States | 2 | <1% |
| Portugal | 1 | <1% |
| Austria | 1 | <1% |
| Pakistan | 1 | <1% |
| Belgium | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 206 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 43 | 20% |
| Researcher | 36 | 17% |
| Student > Master | 28 | 13% |
| Student > Bachelor | 21 | 10% |
| Student > Doctoral Student | 15 | 7% |
| Other | 34 | 16% |
| Unknown | 38 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 61 | 28% |
| Biochemistry, Genetics and Molecular Biology | 43 | 20% |
| Neuroscience | 25 | 12% |
| Medicine and Dentistry | 20 | 9% |
| Chemistry | 6 | 3% |
| Other | 13 | 6% |
| Unknown | 47 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 October 2014.
All research outputs
#6,017,012
of 22,707,247 outputs
Outputs from Frontiers in Neurology
#4,012
of 11,620 outputs
Outputs of similar age
#64,206
of 280,717 outputs
Outputs of similar age from Frontiers in Neurology
#29
of 210 outputs
Altmetric has tracked 22,707,247 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 11,620 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,717 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 210 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.