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The Potential for Bio-Mediators and Biomarkers in Pediatric Traumatic Brain Injury and Neurocritical Care

Overview of attention for article published in Frontiers in Neurology, January 2013
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  • Above-average Attention Score compared to outputs of the same age and source (51st percentile)

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Title
The Potential for Bio-Mediators and Biomarkers in Pediatric Traumatic Brain Injury and Neurocritical Care
Published in
Frontiers in Neurology, January 2013
DOI 10.3389/fneur.2013.00040
Pubmed ID
Authors

Patrick M. Kochanek, Rachel P. Berger, Ericka L. Fink, Alicia K. Au, Hülya Bayır, Michael J. Bell, C. Edward Dixon, Robert S. B. Clark

Abstract

The use of biomarkers of brain injury in pediatric neurocritical care has been explored for at least 15 years. Two general lines of research on biomarkers in pediatric brain injury have been pursued: (1) studies of "bio-mediators" in cerebrospinal fluid (CSF) of children after traumatic brain injury (TBI) to explore the components of the secondary injury cascades in an attempt to identify potential therapeutic targets and (2) studies of the release of structural proteins into the CSF, serum, or urine in order to diagnose, monitor, and/or prognosticate in patients with TBI or other pediatric neurocritical care conditions. Unique age-related differences in brain biology, disease processes, and clinical applications mandate the development and testing of brain injury bio-mediators and biomarkers specifically in pediatric neurocritical care applications. Finally, although much of the early work on biomarkers of brain injury in pediatrics has focused on TBI, new applications are emerging across a wide range of conditions specifically for pediatric neurocritical care including abusive head trauma, cardiopulmonary arrest, septic shock, extracorporeal membrane oxygenation, hydrocephalus, and cardiac surgery. The potential scope of the utility of biomarkers in pediatric neurocritical care is thus also discussed.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
France 1 1%
Unknown 94 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 16%
Student > Master 14 15%
Student > Ph. D. Student 11 11%
Other 10 10%
Student > Bachelor 9 9%
Other 22 23%
Unknown 15 16%
Readers by discipline Count As %
Medicine and Dentistry 51 53%
Neuroscience 7 7%
Psychology 6 6%
Agricultural and Biological Sciences 3 3%
Biochemistry, Genetics and Molecular Biology 3 3%
Other 7 7%
Unknown 19 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2015.
All research outputs
#18,299,839
of 23,509,253 outputs
Outputs from Frontiers in Neurology
#7,387
of 12,429 outputs
Outputs of similar age
#214,188
of 284,626 outputs
Outputs of similar age from Frontiers in Neurology
#83
of 210 outputs
Altmetric has tracked 23,509,253 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 12,429 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.4. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,626 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 210 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.