Title |
Application of Blood-Based Biomarkers in Human Mild Traumatic Brain Injury
|
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Published in |
Frontiers in Neurology, January 2013
|
DOI | 10.3389/fneur.2013.00044 |
Pubmed ID | |
Authors |
Alex P. Di Battista, Shawn G. Rhind, Andrew J. Baker |
Abstract |
Traumatic Brain Injury (TBI) is a global health concern. The majority of TBI's are mild, yet our ability to diagnose and treat mild traumatic brain injury (mTBI) is lacking. This deficiency results from a variety of issues including the difficulty in interpreting ambiguous clinically presented symptoms, and ineffective imaging techniques. Thus, researchers have begun to explore cellular and molecular based approaches to improve both diagnosis and prognosis. This has been met with a variety of challenges, including difficulty in relating biological markers to current clinical symptoms, and overcoming our lack of fundamental understanding of the pathophysiology of mTBI. However, recent adoption of high throughput technologies and a change in focus from the identification of single to multiple markers has given just optimism to mTBI research. The purpose of this review is to highlight a number of current experimental peripheral blood biomarkers of mTBI, as well as comment on the issues surrounding their clinical application and utility. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Mexico | 2 | 40% |
United States | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 129 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 23 | 18% |
Researcher | 21 | 16% |
Student > Bachelor | 20 | 16% |
Student > Ph. D. Student | 17 | 13% |
Professor > Associate Professor | 10 | 8% |
Other | 24 | 19% |
Unknown | 14 | 11% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 42 | 33% |
Agricultural and Biological Sciences | 17 | 13% |
Neuroscience | 15 | 12% |
Psychology | 9 | 7% |
Nursing and Health Professions | 7 | 5% |
Other | 18 | 14% |
Unknown | 21 | 16% |