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Attention Score in Context
| Title |
Long-Term Viral Brain-Derived Neurotrophic Factor Delivery Promotes Spasticity in Rats with a Cervical Spinal Cord Hemisection
|
|---|---|
| Published in |
Frontiers in Neurology, January 2013
|
| DOI | 10.3389/fneur.2013.00187 |
| Pubmed ID | |
| Authors |
Karim Fouad, David J. Bennett, Romana Vavrek, Armin Blesch |
| Abstract |
We have recently reported that rats with complete thoracic spinal cord injury (SCI) that received a combinatorial treatment, including viral brain-derived neurotrophic factor (BDNF) delivery in the spinal cord, not only showed enhanced axonal regeneration, but also deterioration of hind-limb motor function. By demonstrating that BDNF over-expression can trigger spasticity-like symptoms in a rat model of sacral SCI, we proposed a causal relationship between the observed spasticity-like symptoms (i.e., resistance to passive range of motion) and the over-expression of BDNF. The current study was originally designed to evaluate a comparable combined treatment for cervical SCI in the rat to improve motor recovery. Once again we found similar signs of spasticity involving clenching of the paws and wrist flexion. This finding changed the focus of the study and, we then explored whether this spasticity-like symptom is directly related to the over-expression of BDNF by administering a BDNF antagonist. Using electromyographic measurements we showed that this treatment gradually diminished the resistance to overcome forelimb flexion in an acute experiment. Thus, we conclude that neuro-excitatory effects of chronic BDNF delivery together with diminished descending control after SCI can result in adverse effects. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 57 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 14% |
| Student > Master | 7 | 12% |
| Researcher | 5 | 9% |
| Professor | 5 | 9% |
| Student > Bachelor | 5 | 9% |
| Other | 11 | 19% |
| Unknown | 16 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 13 | 23% |
| Medicine and Dentistry | 8 | 14% |
| Biochemistry, Genetics and Molecular Biology | 6 | 11% |
| Agricultural and Biological Sciences | 3 | 5% |
| Nursing and Health Professions | 2 | 4% |
| Other | 6 | 11% |
| Unknown | 19 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 November 2013.
All research outputs
#20,210,424
of 22,731,677 outputs
Outputs from Frontiers in Neurology
#8,642
of 11,635 outputs
Outputs of similar age
#248,807
of 280,774 outputs
Outputs of similar age from Frontiers in Neurology
#117
of 210 outputs
Altmetric has tracked 22,731,677 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,635 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,774 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 210 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.