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Combination of PET and Magnetoencephalography in the Presurgical Assessment of MRI-Negative Epilepsy

Overview of attention for article published in Frontiers in Neurology, January 2013
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Title
Combination of PET and Magnetoencephalography in the Presurgical Assessment of MRI-Negative Epilepsy
Published in
Frontiers in Neurology, January 2013
DOI 10.3389/fneur.2013.00188
Pubmed ID
Authors

Sylvain Rheims, Julien Jung, Philippe Ryvlin

Abstract

Despite major advances in neuroimaging, no lesion is visualized on MRI in up to a quarter of patients with drug-resistant focal epilepsy presenting for presurgical evaluation. These patients demonstrate poorer surgical outcomes than those with lesion seen on MRI. Accurate localization of the seizure onset zone (SOZ) is more difficult in MRI-negative patients and often requires invasive EEG recordings. Positron emission tomography (PET) and magnetoencephalography (MEG) have been proposed as clinically relevant tools to localize the SOZ prior to intracranial EEG recordings. However, there is no consensus regarding the optimal gold standard that should be used for assessing the performance of these presurgical investigations. Here, we review the current knowledge concerning the usefulness of PET and MEG for presurgical assessment of MRI-negative epilepsy. Beyond the individual diagnostic performance of MEG and of different PET tracers, including [(18)F]-fluorodeoxyglucose, [(11)C]flumazenil, and markers of 5-HT1A receptors, recent data suggest that the combination of PET and MEG might provide greater sensitivity and specificity than that of each of the two individual tests in patients with normal MRI.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Unknown 54 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 20%
Unspecified 8 15%
Student > Master 6 11%
Other 5 9%
Student > Ph. D. Student 5 9%
Other 12 22%
Unknown 8 15%
Readers by discipline Count As %
Medicine and Dentistry 23 42%
Unspecified 8 15%
Neuroscience 7 13%
Agricultural and Biological Sciences 3 5%
Engineering 2 4%
Other 4 7%
Unknown 8 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 November 2013.
All research outputs
#20,210,424
of 22,731,677 outputs
Outputs from Frontiers in Neurology
#8,642
of 11,635 outputs
Outputs of similar age
#248,807
of 280,774 outputs
Outputs of similar age from Frontiers in Neurology
#117
of 210 outputs
Altmetric has tracked 22,731,677 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,635 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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