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White Matter Disease Correlates with Lexical Retrieval Deficits in Primary Progressive Aphasia

Overview of attention for article published in Frontiers in Neurology, January 2013
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Title
White Matter Disease Correlates with Lexical Retrieval Deficits in Primary Progressive Aphasia
Published in
Frontiers in Neurology, January 2013
DOI 10.3389/fneur.2013.00212
Pubmed ID
Authors

John P. Powers, Corey T. McMillan, Caroline C. Brun, Paul A. Yushkevich, Hui Zhang, James C. Gee, Murray Grossman

Abstract

Objective: To relate fractional anisotropy (FA) changes associated with the semantic and logopenic variants of primary progressive aphasia (PPA) to measures of lexical retrieval. Methods: We collected neuropsychological testing, volumetric magnetic resonance imaging, and diffusion-weighted imaging on semantic variant PPA (svPPA) (n = 11) and logopenic variant PPA (lvPPA) (n = 13) patients diagnosed using published criteria. We also acquired neuroimaging data on a group of demographically comparable healthy seniors (n = 34). FA was calculated and analyzed using a white matter (WM) tract-specific analysis approach. This approach utilizes anatomically guided data reduction to increase sensitivity and localizes results within canonically defined tracts. We used non-parametric, cluster-based statistical analysis to relate language performance to FA and determine regions of reduced FA in patients. Results: We found widespread FA reductions in WM for both variants of PPA. FA was related to both confrontation naming and category naming fluency performance in left uncinate fasciculus and corpus callosum in svPPA and left superior and inferior longitudinal fasciculi in lvPPA. Conclusion: SvPPA and lvPPA are associated with distinct disruptions of a large-scale network implicated in lexical retrieval, and the WM disease in each phenotype may contribute to language impairments including lexical retrieval.

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Mendeley readers

Mendeley readers

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Geographical breakdown

Country Count As %
United States 1 2%
France 1 2%
Canada 1 2%
Brazil 1 2%
Unknown 46 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 20%
Researcher 8 16%
Student > Master 8 16%
Professor 4 8%
Student > Bachelor 4 8%
Other 12 24%
Unknown 4 8%
Readers by discipline Count As %
Psychology 11 22%
Neuroscience 10 20%
Medicine and Dentistry 10 20%
Agricultural and Biological Sciences 6 12%
Linguistics 4 8%
Other 1 2%
Unknown 8 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 December 2013.
All research outputs
#17,706,524
of 22,736,112 outputs
Outputs from Frontiers in Neurology
#7,007
of 11,645 outputs
Outputs of similar age
#210,238
of 280,808 outputs
Outputs of similar age from Frontiers in Neurology
#84
of 210 outputs
Altmetric has tracked 22,736,112 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,645 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,808 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 210 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.