Title |
Mechanisms of Body Weight Fluctuations in Parkinson’s Disease
|
---|---|
Published in |
Frontiers in Neurology, June 2014
|
DOI | 10.3389/fneur.2014.00084 |
Pubmed ID | |
Authors |
Andrea Kistner, Eugénie Lhommée, Paul Krack |
Abstract |
Typical body weight changes are known to occur in Parkinson's disease (PD). Weight loss has been reported in early stages as well as in advanced disease and malnutrition may worsen the clinical state of the patient. On the other hand, an increasing number of patients show weight gain under dopamine replacement therapy or after surgery. These weight changes are multifactorial and involve changes in energy expenditure, perturbation of homeostatic control, and eating behavior modulated by dopaminergic treatment. Comprehension of the different mechanisms contributing to body weight is a prerequisite for the management of body weight and nutritional state of an individual PD patient. This review summarizes the present knowledge and highlights the necessity of evaluation of body weight and related factors, as eating behavior, energy intake, and expenditure in PD. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Unknown | 125 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 22 | 17% |
Student > Master | 19 | 15% |
Student > Ph. D. Student | 17 | 13% |
Student > Bachelor | 15 | 12% |
Other | 8 | 6% |
Other | 19 | 15% |
Unknown | 26 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 28 | 22% |
Neuroscience | 23 | 18% |
Agricultural and Biological Sciences | 12 | 10% |
Nursing and Health Professions | 7 | 6% |
Psychology | 6 | 5% |
Other | 14 | 11% |
Unknown | 36 | 29% |