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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Pedunculopontine Nucleus Gamma Band Activity-Preconscious Awareness, Waking, and REM Sleep
|
|---|---|
| Published in |
Frontiers in Neurology, October 2014
|
| DOI | 10.3389/fneur.2014.00210 |
| Pubmed ID | |
| Authors |
Francisco J. Urbano, Stasia M. D’Onofrio, Brennon R. Luster, Paige B. Beck, James Robert Hyde, Veronica Bisagno, Edgar Garcia-Rill |
| Abstract |
The pedunculopontine nucleus (PPN) is a major component of the reticular activating system (RAS) that regulates waking and REM sleep, states of high-frequency EEG activity. Recently, we described the presence of high threshold, voltage-dependent N- and P/Q-type calcium channels in RAS nuclei that subserve gamma band oscillations in the mesopontine PPN, intralaminar parafascicular nucleus (Pf), and pontine subcoeruleus nucleus dorsalis (SubCD). Cortical gamma band activity participates in sensory perception, problem solving, and memory. Rather than participating in the temporal binding of sensory events as in the cortex, gamma band activity in the RAS may participate in the processes of preconscious awareness, and provide the essential stream of information for the formulation of many of our actions. That is, the RAS may play an early permissive role in volition. Our latest results suggest that (1) the manifestation of gamma band activity during waking may employ a separate intracellular pathway compared to that during REM sleep, (2) neuronal calcium sensor (NCS-1) protein, which is over expressed in schizophrenia and bipolar disorder, modulates gamma band oscillations in the PPN in a concentration-dependent manner, (3) leptin, which undergoes resistance in obesity resulting in sleep dysregulation, decreases sodium currents in PPN neurons, accounting for its normal attenuation of waking, and (4) following our discovery of electrical coupling in the RAS, we hypothesize that there are cell clusters within the PPN that may act in concert. These results provide novel information on the mechanisms controlling high-frequency activity related to waking and REM sleep by elements of the RAS. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Canada | 1 | 1% |
| Belgium | 1 | 1% |
| United States | 1 | 1% |
| Serbia | 1 | 1% |
| Unknown | 66 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 20% |
| Researcher | 10 | 14% |
| Student > Bachelor | 6 | 8% |
| Student > Master | 5 | 7% |
| Student > Doctoral Student | 4 | 6% |
| Other | 17 | 24% |
| Unknown | 15 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 15 | 21% |
| Medicine and Dentistry | 13 | 18% |
| Psychology | 8 | 11% |
| Agricultural and Biological Sciences | 7 | 10% |
| Nursing and Health Professions | 2 | 3% |
| Other | 6 | 8% |
| Unknown | 20 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2014.
All research outputs
#18,381,794
of 22,768,097 outputs
Outputs from Frontiers in Neurology
#7,687
of 11,665 outputs
Outputs of similar age
#185,349
of 259,226 outputs
Outputs of similar age from Frontiers in Neurology
#54
of 83 outputs
Altmetric has tracked 22,768,097 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,665 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 259,226 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.