Title |
Penfield’s Prediction: A Mechanism for Deep Brain Stimulation
|
---|---|
Published in |
Frontiers in Neurology, October 2014
|
DOI | 10.3389/fneur.2014.00213 |
Pubmed ID | |
Authors |
Richard W. Murrow |
Abstract |
Despite its widespread use, the precise mechanism of action of Deep Brain Stimulation (DBS) therapy remains unknown. The modern urgency to publish more and new data can obscure previously learned lessons by the giants who have preceded us and whose shoulders we now stand upon. Wilder Penfield extensively studied the effects of artificial electrical brain stimulation and his comments on the subject are still very relevant today. In particular, he noted two very different (and seemingly opposite) effects of stimulation within the human brain. In some structures, artificial electrical stimulation has an effect, which mimics ablation, while, in other structures, it produces a stimulatory effect on that tissue. |
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