Title |
Clinical Features in Patients with Long-Lasting Macrophagic Myofasciitis
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Published in |
Frontiers in Neurology, November 2014
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DOI | 10.3389/fneur.2014.00230 |
Pubmed ID | |
Authors |
Muriel Rigolet, Jessie Aouizerate, Maryline Couette, Nilusha Ragunathan-Thangarajah, Mehdi Aoun-Sebaiti, Romain Kroum Gherardi, Josette Cadusseau, François Jérôme Authier |
Abstract |
Macrophagic myofasciitis (MMF) is an emerging condition characterized by specific muscle lesions assessing abnormal long-term persistence of aluminum hydroxide within macrophages at the site of previous immunization. Affected patients usually are middle-aged adults, mainly presenting with diffuse arthromyalgias, chronic fatigue, and marked cognitive deficits, not related to pain, fatigue, or depression. Clinical features usually correspond to that observed in chronic fatigue syndrome/myalgic encephalomyelitis. Representative features of MMF-associated cognitive dysfunction include dysexecutive syndrome, visual memory impairment, and left ear extinction at dichotic listening test. Most patients fulfill criteria for non-amnestic/dysexecutive mild cognitive impairment, even if some cognitive deficits appear unusually severe. Cognitive dysfunction seems stable over time despite marked fluctuations. Evoked potentials may show abnormalities in keeping with central nervous system involvement, with a neurophysiological pattern suggestive of demyelination. Brain perfusion SPECT shows a pattern of diffuse cortical and subcortical abnormalities, with hypoperfusions correlating with cognitive deficiencies. The combination of musculoskeletal pain, chronic fatigue, and cognitive disturbance generates chronic disability with possible social exclusion. Classical therapeutic approaches are usually unsatisfactory making patient care difficult. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 15 | 27% |
France | 2 | 4% |
Canada | 2 | 4% |
Côte d'Ivoire | 1 | 2% |
United Kingdom | 1 | 2% |
Australia | 1 | 2% |
Italy | 1 | 2% |
India | 1 | 2% |
Japan | 1 | 2% |
Other | 3 | 5% |
Unknown | 27 | 49% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 44 | 80% |
Practitioners (doctors, other healthcare professionals) | 8 | 15% |
Science communicators (journalists, bloggers, editors) | 1 | 2% |
Scientists | 1 | 2% |
Unknown | 1 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
Unknown | 60 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 11% |
Student > Ph. D. Student | 7 | 11% |
Student > Doctoral Student | 7 | 11% |
Student > Bachelor | 6 | 10% |
Researcher | 5 | 8% |
Other | 13 | 21% |
Unknown | 16 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 21% |
Psychology | 10 | 16% |
Agricultural and Biological Sciences | 5 | 8% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Other | 11 | 18% |
Unknown | 16 | 26% |