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The Role of Epigenetic Change in Autism Spectrum Disorders

Overview of attention for article published in Frontiers in Neurology, May 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
2 news outlets
blogs
4 blogs
twitter
40 X users
patent
1 patent
facebook
5 Facebook pages
googleplus
3 Google+ users

Readers on

mendeley
449 Mendeley
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Title
The Role of Epigenetic Change in Autism Spectrum Disorders
Published in
Frontiers in Neurology, May 2015
DOI 10.3389/fneur.2015.00107
Pubmed ID
Authors

Yuk Jing Loke, Anthony John Hannan, Jeffrey Mark Craig

Abstract

Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental disorders characterized by problems with social communication, social interaction, and repetitive or restricted behaviors. ASD are comorbid with other disorders including attention deficit hyperactivity disorder, epilepsy, Rett syndrome, and Fragile X syndrome. Neither the genetic nor the environmental components have been characterized well enough to aid diagnosis or treatment of non-syndromic ASD. However, genome-wide association studies have amassed evidence suggesting involvement of hundreds of genes and a variety of associated genetic pathways. Recently, investigators have turned to epigenetics, a prime mediator of environmental effects on genomes and phenotype, to characterize changes in ASD that constitute a molecular level on top of DNA sequence. Though in their infancy, such studies have the potential to increase our understanding of the etiology of ASD and may assist in the development of biomarkers for its prediction, diagnosis, prognosis, and eventually in its prevention and intervention. This review focuses on the first few epigenome-wide association studies of ASD and discusses future directions.

X Demographics

X Demographics

The data shown below were collected from the profiles of 40 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 449 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
Italy 1 <1%
Brazil 1 <1%
Canada 1 <1%
United Kingdom 1 <1%
Korea, Republic of 1 <1%
Mexico 1 <1%
Unknown 441 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 85 19%
Researcher 65 14%
Student > Bachelor 58 13%
Student > Master 53 12%
Student > Doctoral Student 31 7%
Other 77 17%
Unknown 80 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 69 15%
Medicine and Dentistry 65 14%
Neuroscience 63 14%
Biochemistry, Genetics and Molecular Biology 57 13%
Psychology 37 8%
Other 55 12%
Unknown 103 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 75. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2023.
All research outputs
#579,276
of 25,654,806 outputs
Outputs from Frontiers in Neurology
#205
of 14,766 outputs
Outputs of similar age
#6,392
of 280,947 outputs
Outputs of similar age from Frontiers in Neurology
#2
of 77 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,766 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.5. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,947 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.