Title |
Manganese-Enhanced MRI: Biological Applications in Neuroscience
|
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Published in |
Frontiers in Neurology, July 2015
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DOI | 10.3389/fneur.2015.00161 |
Pubmed ID | |
Authors |
Jackeline Moraes Malheiros, Fernando Fernandes Paiva, Beatriz Monteiro Longo, Clement Hamani, Luciene Covolan |
Abstract |
Magnetic resonance imaging (MRI) is an excellent non-invasive tool to investigate biological systems. The administration of the paramagnetic divalent ion manganese (Mn(2+)) enhances MRI contrast in vivo. Due to similarities between Mn(2+) and calcium (Ca(2+)), the premise of manganese-enhanced MRI (MEMRI) is that the former may enter neurons and other excitable cells through voltage-gated Ca(2+) channels. As such, MEMRI has been used to trace neuronal pathways, define morphological boundaries, and study connectivity in morphological and functional imaging studies. In this article, we provide a brief overview of MEMRI and discuss recently published data to illustrate the usefulness of this method, particularly in animal models. |
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Mendeley readers
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Student > Ph. D. Student | 17 | 21% |
Researcher | 14 | 18% |
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Other | 6 | 8% |
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