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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?
|
|---|---|
| Published in |
Frontiers in Neurology, September 2015
|
| DOI | 10.3389/fneur.2015.00192 |
| Pubmed ID | |
| Authors |
Elisa Evangelista, Christian Bénar, Francesca Bonini, Romain Carron, Bruno Colombet, Jean Régis, Fabrice Bartolomei |
| Abstract |
The mechanisms underlying seizure termination are still unclear despite their therapeutic importance. We studied thalamo-cortical connectivity and synchrony in human mesial temporal lobe seizures in order to analyze their role in seizure termination. Twenty-two seizures from 10 patients with drug-resistant mesial temporal lobe epilepsy undergoing pre-surgical evaluation were analyzed using intracerebral recordings [stereoelectroencephalography (SEEG)]. We performed a measure of SEEG signal interdependencies (non-linear correlation), to estimate the functional connectivity between thalamus and cortical regions. Then, we derived synchronization indices, namely global, thalamic, mesio-temporal, and thalamo-mesio temporal index at the onset and the end of seizures. In addition, an estimation of thalamic "outputs and inputs" connectivity was proposed. Thalamus was consistently involved in the last phase of all analyzed seizures and thalamic synchronization index was significantly more elevated at the end of seizure than at the onset. The global synchronization index at the end of seizure negatively correlated with seizure duration (p = 0.045) and in the same way the thalamic synchronization index showed an inverse tendency with seizure duration. Six seizures out of twenty-two displayed a particular thalamo-cortical spike-and-wave pattern at the end. They were associated to higher values of all synchronization indices and outputs from thalamus (p = 0.0079). SWP seizures displayed a higher and sustained increase of cortical and thalamo-cortical synchronization with a stronger participation of thalamic outputs. We suggest that thalamo-cortical oscillations might contribute to seizure termination via modulation of cortical synchronization. In the subgroup of SWP seizures, thalamus may exert a control on temporal lobe structures by inducing a stable hypersynchronization that ultimately leads to seizure termination. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 33% |
| Switzerland | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 1% |
| Unknown | 98 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 17% |
| Researcher | 16 | 16% |
| Unspecified | 11 | 11% |
| Student > Bachelor | 9 | 9% |
| Student > Master | 8 | 8% |
| Other | 24 | 24% |
| Unknown | 14 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 21 | 21% |
| Medicine and Dentistry | 20 | 20% |
| Unspecified | 11 | 11% |
| Agricultural and Biological Sciences | 9 | 9% |
| Engineering | 9 | 9% |
| Other | 9 | 9% |
| Unknown | 20 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2018.
All research outputs
#17,772,019
of 22,826,360 outputs
Outputs from Frontiers in Neurology
#7,059
of 11,712 outputs
Outputs of similar age
#180,036
of 266,863 outputs
Outputs of similar age from Frontiers in Neurology
#40
of 52 outputs
Altmetric has tracked 22,826,360 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,712 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,863 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.