Title |
Blood-Based Proteomic Biomarkers of Alzheimer’s Disease Pathology
|
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Published in |
Frontiers in Neurology, November 2015
|
DOI | 10.3389/fneur.2015.00236 |
Pubmed ID | |
Authors |
Alison L. Baird, Sarah Westwood, Simon Lovestone |
Abstract |
The complexity of Alzheimer's disease (AD) and its long prodromal phase poses challenges for early diagnosis and yet allows for the possibility of the development of disease modifying treatments for secondary prevention. It is, therefore, of importance to develop biomarkers, in particular, in the preclinical or early phases that reflect the pathological characteristics of the disease and, moreover, could be of utility in triaging subjects for preventative therapeutic clinical trials. Much research has sought biomarkers for diagnostic purposes by comparing affected people to unaffected controls. However, given that AD pathology precedes disease onset, a pathology endophenotype design for biomarker discovery creates the opportunity for detection of much earlier markers of disease. Blood-based biomarkers potentially provide a minimally invasive option for this purpose and research in the field has adopted various "omics" approaches in order to achieve this. This review will, therefore, examine the current literature regarding blood-based proteomic biomarkers of AD and its associated pathology. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 38% |
United States | 1 | 13% |
Switzerland | 1 | 13% |
Unknown | 3 | 38% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 50% |
Scientists | 2 | 25% |
Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Science communicators (journalists, bloggers, editors) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | <1% |
Italy | 1 | <1% |
Unknown | 193 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 43 | 22% |
Researcher | 36 | 18% |
Student > Master | 26 | 13% |
Student > Bachelor | 19 | 10% |
Other | 12 | 6% |
Other | 27 | 14% |
Unknown | 32 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 31 | 16% |
Neuroscience | 31 | 16% |
Agricultural and Biological Sciences | 26 | 13% |
Medicine and Dentistry | 19 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 10 | 5% |
Other | 35 | 18% |
Unknown | 43 | 22% |