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Blood-Based Proteomic Biomarkers of Alzheimer’s Disease Pathology

Overview of attention for article published in Frontiers in Neurology, November 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

Mentioned by

news
1 news outlet
twitter
8 X users
facebook
1 Facebook page

Citations

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99 Dimensions

Readers on

mendeley
195 Mendeley
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Title
Blood-Based Proteomic Biomarkers of Alzheimer’s Disease Pathology
Published in
Frontiers in Neurology, November 2015
DOI 10.3389/fneur.2015.00236
Pubmed ID
Authors

Alison L. Baird, Sarah Westwood, Simon Lovestone

Abstract

The complexity of Alzheimer's disease (AD) and its long prodromal phase poses challenges for early diagnosis and yet allows for the possibility of the development of disease modifying treatments for secondary prevention. It is, therefore, of importance to develop biomarkers, in particular, in the preclinical or early phases that reflect the pathological characteristics of the disease and, moreover, could be of utility in triaging subjects for preventative therapeutic clinical trials. Much research has sought biomarkers for diagnostic purposes by comparing affected people to unaffected controls. However, given that AD pathology precedes disease onset, a pathology endophenotype design for biomarker discovery creates the opportunity for detection of much earlier markers of disease. Blood-based biomarkers potentially provide a minimally invasive option for this purpose and research in the field has adopted various "omics" approaches in order to achieve this. This review will, therefore, examine the current literature regarding blood-based proteomic biomarkers of AD and its associated pathology.

X Demographics

X Demographics

The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 195 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Italy 1 <1%
Unknown 193 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 43 22%
Researcher 36 18%
Student > Master 26 13%
Student > Bachelor 19 10%
Other 12 6%
Other 27 14%
Unknown 32 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 31 16%
Neuroscience 31 16%
Agricultural and Biological Sciences 26 13%
Medicine and Dentistry 19 10%
Pharmacology, Toxicology and Pharmaceutical Science 10 5%
Other 35 18%
Unknown 43 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2016.
All research outputs
#2,106,381
of 22,833,393 outputs
Outputs from Frontiers in Neurology
#1,008
of 11,712 outputs
Outputs of similar age
#28,693
of 252,470 outputs
Outputs of similar age from Frontiers in Neurology
#10
of 61 outputs
Altmetric has tracked 22,833,393 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,712 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,470 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.