Title |
Microglial Cells as a Link between Cannabinoids and the Immune Hypothesis of Psychiatric Disorders
|
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Published in |
Frontiers in Neurology, January 2016
|
DOI | 10.3389/fneur.2016.00005 |
Pubmed ID | |
Authors |
Sabrina F. Lisboa, Felipe V. Gomes, Francisco S. Guimaraes, Alline C. Campos |
Abstract |
Psychiatric disorders are one of the leading causes of disability worldwide. Although several therapeutic options are available, the exact mechanisms responsible for the genesis of these disorders remain to be fully elucidated. In the last decade, a body of evidence has supported the involvement of the immune system in the pathophysiology of these conditions. Microglial cells play a significant role in maintaining brain homeostasis and surveillance. Dysregulation of microglial functions has been associated with several psychiatric conditions. Cannabinoids regulate the brain-immune axis and inhibit microglial cell activation. Here, we summarized evidence supporting the hypothesis that microglial cells could be a target for cannabinoid influence on psychiatric disorders, such as anxiety, depression, schizophrenia, and stress-related disorders. |
X Demographics
Geographical breakdown
Country | Count | As % |
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China | 1 | 17% |
Switzerland | 1 | 17% |
Unknown | 4 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Iran, Islamic Republic of | 1 | <1% |
United Kingdom | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 162 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 28 | 17% |
Student > Ph. D. Student | 27 | 16% |
Student > Master | 25 | 15% |
Researcher | 23 | 14% |
Other | 10 | 6% |
Other | 19 | 12% |
Unknown | 33 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 38 | 23% |
Agricultural and Biological Sciences | 20 | 12% |
Biochemistry, Genetics and Molecular Biology | 17 | 10% |
Medicine and Dentistry | 17 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 13 | 8% |
Other | 17 | 10% |
Unknown | 43 | 26% |