Title |
High-Resolution Microfluidic Single-Cell Transcriptional Profiling Reveals Clinically Relevant Subtypes among Human Stem Cell Populations Commonly Utilized in Cell-Based Therapies
|
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Published in |
Frontiers in Neurology, March 2016
|
DOI | 10.3389/fneur.2016.00041 |
Pubmed ID | |
Authors |
Robert C. Rennert, Richard Schäfer, Tonya Bliss, Michael Januszyk, Michael Sorkin, Achal S. Achrol, Melanie Rodrigues, Zeshaan N. Maan, Torsten Kluba, Gary K. Steinberg, Geoffrey C. Gurtner |
Abstract |
Stem cell therapies can promote neural repair and regeneration, yet controversy regarding optimal cell source and mechanism of action has slowed clinical translation, potentially due to undefined cellular heterogeneity. Single-cell resolution is needed to identify clinically relevant subpopulations with the highest therapeutic relevance. We combine single-cell microfluidic analysis with advanced computational modeling to study for the first time two common sources for cell-based therapies, human NSCs and MSCs. This methodology has the potential to logically inform cell source decisions for any clinical application. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 28 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 18% |
Other | 4 | 14% |
Researcher | 4 | 14% |
Student > Bachelor | 3 | 11% |
Professor | 2 | 7% |
Other | 5 | 18% |
Unknown | 5 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 5 | 18% |
Engineering | 3 | 11% |
Medicine and Dentistry | 3 | 11% |
Neuroscience | 2 | 7% |
Agricultural and Biological Sciences | 1 | 4% |
Other | 3 | 11% |
Unknown | 11 | 39% |