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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Does Side of Onset Influence the Pattern of Cerebral Atrophy in Parkinson’s Disease?
|
|---|---|
| Published in |
Frontiers in Neurology, September 2016
|
| DOI | 10.3389/fneur.2016.00145 |
| Pubmed ID | |
| Authors |
Maria C. A. Santos, Lidiane S. Campos, Rachel P. Guimarães, Camila C. Piccinin, Paula C. Azevedo, Luiza G. Piovesana, Brunno Machado De Campos, Augusto C. Scarparo Amato-Filho, Fernando Cendes, Anelyssa D’Abreu |
| Abstract |
Imaging studies have revealed widespread neurodegeneration in Parkinson's disease (PD), but only a few considered the issue of asymmetrical clinical presentations. To investigate if the side of onset influences the pattern of gray matter (GM) atrophy in PD. Sixty patients (57.87 ± 10.27 years) diagnosed with idiopathic PD according to the U.K. Brain Bank criteria, 26 with right-sided disease onset (RDO) and 34 with left-sided disease onset (LDO), were compared to 80 healthy controls (HC) (57.1 ± 9.47 years). We acquired T1-weighted images on a 3 T scanner. Images were processed and analyzed with VBM8 (SPM8/Dartel) on Matlab R2012b platform. Statistic assessments included a two-sample test (family-wise error p < 0.05) with extent threshold of 20 voxels. Compared to HC, LDO patients had GM atrophy in the insula, putamen, anterior cingulate, frontotemporal cortex, and right caudate, while the RDO group showed atrophy at the anterior cingulate, insula, frontotemporal, and occipital cortex. This study revealed widespread GM atrophy in PD, predominantly in the left hemisphere, regardless of the side of onset. Future investigations should also consider handedness and side of onset to better characterize cerebral involvement and its progression in PD. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 30 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 17% |
| Researcher | 4 | 13% |
| Student > Bachelor | 3 | 10% |
| Professor | 3 | 10% |
| Student > Master | 3 | 10% |
| Other | 5 | 17% |
| Unknown | 7 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 11 | 37% |
| Medicine and Dentistry | 6 | 20% |
| Psychology | 3 | 10% |
| Biochemistry, Genetics and Molecular Biology | 1 | 3% |
| Agricultural and Biological Sciences | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 7 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2016.
All research outputs
#3,210,138
of 22,888,307 outputs
Outputs from Frontiers in Neurology
#2,633
of 11,809 outputs
Outputs of similar age
#56,653
of 322,308 outputs
Outputs of similar age from Frontiers in Neurology
#13
of 65 outputs
Altmetric has tracked 22,888,307 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,809 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,308 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.