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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Patterns of Co-Occurring Gray Matter Concentration Loss across the Huntington Disease Prodrome
|
|---|---|
| Published in |
Frontiers in Neurology, September 2016
|
| DOI | 10.3389/fneur.2016.00147 |
| Pubmed ID | |
| Authors |
Jennifer Ashley Ciarochi, Vince D. Calhoun, Spencer Lourens, Jeffrey D. Long, Hans J. Johnson, H. Jeremy Bockholt, Jingyu Liu, Sergey M. Plis, Jane S. Paulsen, Jessica A. Turner, The PREDICT-HD Investigators and Coordinators of the Huntington Study Group |
| Abstract |
Huntington disease (HD) is caused by an abnormally expanded cytosine-adenine-guanine (CAG) trinucleotide repeat in the HTT gene. Age and CAG-expansion number are related to age at diagnosis and can be used to index disease progression. However, observed onset-age variability suggests that other factors also modulate progression. Indexing prodromal (pre-diagnosis) progression may highlight therapeutic targets by isolating the earliest-affected factors. We present the largest prodromal HD application of the univariate method voxel-based morphometry (VBM) and the first application of the multivariate method source-based morphometry (SBM) to, respectively, compare gray matter concentration (GMC) and capture co-occurring GMC patterns in control and prodromal participants. Using structural MRI data from 1050 (831 prodromal, 219 control) participants, we characterize control-prodromal, whole-brain GMC differences at various prodromal stages. Our results provide evidence for (1) regional co-occurrence and differential patterns of decline across the prodrome, with parietal and occipital differences commonly co-occurring, and frontal and temporal differences being relatively independent from one another, (2) fronto-striatal circuits being among the earliest and most consistently affected in the prodrome, (3) delayed degradation in some movement-related regions, with increasing subcortical and occipital differences with later progression, (4) an overall superior-to-inferior gradient of GMC reduction in frontal, parietal, and temporal lobes, and (5) the appropriateness of SBM for studying the prodromal HD population and its enhanced sensitivity to early prodromal and regionally concurrent differences. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 2% |
| Unknown | 40 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 17% |
| Researcher | 6 | 15% |
| Student > Master | 4 | 10% |
| Student > Bachelor | 3 | 7% |
| Professor | 3 | 7% |
| Other | 8 | 20% |
| Unknown | 10 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 6 | 15% |
| Psychology | 4 | 10% |
| Engineering | 4 | 10% |
| Medicine and Dentistry | 4 | 10% |
| Nursing and Health Professions | 3 | 7% |
| Other | 6 | 15% |
| Unknown | 14 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2016.
All research outputs
#20,342,896
of 22,889,074 outputs
Outputs from Frontiers in Neurology
#8,820
of 11,810 outputs
Outputs of similar age
#278,295
of 320,659 outputs
Outputs of similar age from Frontiers in Neurology
#52
of 68 outputs
Altmetric has tracked 22,889,074 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,810 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,659 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.