Title |
The Role of Osteopontin and Its Gene on Glucocorticoid Response in Myasthenia Gravis
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Published in |
Frontiers in Neurology, May 2017
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DOI | 10.3389/fneur.2017.00230 |
Pubmed ID | |
Authors |
Yanchen Xie, Hai-Feng Li, Liang Sun, Linda L. Kusner, Shuhui Wang, Yunxiao Meng, Xu Zhang, Yu Hong, Xiang Gao, Yao Li, Henry J. Kaminski |
Abstract |
Biomarkers that assess treatment response for patients with the autoimmune disorder, myasthenia gravis (MG), have not been evaluated to a significant extent. We hypothesized the pro-inflammatory cytokine, osteopontin (OPN), may be associated with variability of response to glucocorticoids (GCs) in patients with MG. A cohort of 250 MG patients treated with standardized protocol of GCs was recruited, and plasma OPN and polymorphisms of its gene, secreted phosphoprotein 1 (SPP1), were evaluated. Mean OPN levels were higher in patients compared to healthy controls. Carriers of rs11728697*T allele (allele definition: one of two or more alternative forms of a gene) were more frequent in the poorly GC responsive group compared to the GC responsive group indicating an association of rs11728697*T allele with GC non-responsiveness. One risk haplotype (AGTACT) was identified associated with GC non-responsiveness compared with GC responsive MG group. Genetic variations of SPP1 were found associated with the response to GC among MG patients. |
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 14 | 100% |
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Other | 3 | 21% |
Researcher | 3 | 21% |
Student > Ph. D. Student | 1 | 7% |
Student > Bachelor | 1 | 7% |
Student > Master | 1 | 7% |
Other | 1 | 7% |
Unknown | 4 | 29% |
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Unknown | 4 | 29% |