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Fish Oil Supplementation Reduces Heart Levels of Interleukin-6 in Rats with Chronic Inflammation due to Epilepsy

Overview of attention for article published in Frontiers in Neurology, June 2017
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Title
Fish Oil Supplementation Reduces Heart Levels of Interleukin-6 in Rats with Chronic Inflammation due to Epilepsy
Published in
Frontiers in Neurology, June 2017
DOI 10.3389/fneur.2017.00263
Pubmed ID
Authors

Mariana Bocca Nejm, André Abou Haidar, Aparecida Emiko Hirata, Lila Missae Oyama, Antonio-Carlos Guimarães de Almeida, Roberta Monterazzo Cysneiros, Esper Abrão Cavalheiro, Carla Alessandra Scorza, Fulvio Alexandre Scorza

Abstract

Sudden unexpected death in epilepsy (SUDEP) is a major cause of premature death related to epilepsy. The causes of SUDEP remain unknown, but cardiac arrhythmias and asphyxia have been suggested as a major mechanism of this event. Inflammation has been implicated in the pathogenesis of both epilepsy and ventricular arrhythmia, with interleukin-6 (IL-6) being recognized as a crucial orchestrator of inflammatory states. Our group previously reported that levels of IL-6 were increased in the hearts of epileptic rats. In this scenario, anti-inflammatory actions are among the beneficial effects of fish oil dietary supplementation. This investigation revealed that elevated levels of IL-6 in the heart were markedly reduced in epileptic rats that were treated in the long-term with fish oil, suggesting protective anti-inflammatory actions against dangerously high levels of IL-6. Based on these findings, our results suggest beneficial effects of long-term intake of fish oil in reducing the inflammation associated with chronic epilepsy.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 27%
Student > Doctoral Student 2 13%
Professor 2 13%
Professor > Associate Professor 2 13%
Student > Ph. D. Student 1 7%
Other 3 20%
Unknown 1 7%
Readers by discipline Count As %
Neuroscience 6 40%
Biochemistry, Genetics and Molecular Biology 2 13%
Medicine and Dentistry 2 13%
Engineering 1 7%
Unknown 4 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 September 2017.
All research outputs
#13,557,147
of 22,979,862 outputs
Outputs from Frontiers in Neurology
#5,292
of 11,865 outputs
Outputs of similar age
#161,467
of 317,132 outputs
Outputs of similar age from Frontiers in Neurology
#84
of 193 outputs
Altmetric has tracked 22,979,862 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,865 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,132 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 193 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.