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Cerebrospinal Fluid and Microdialysis Cytokines in Aneurysmal Subarachnoid Hemorrhage: A Scoping Systematic Review

Overview of attention for article published in Frontiers in Neurology, August 2017
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Title
Cerebrospinal Fluid and Microdialysis Cytokines in Aneurysmal Subarachnoid Hemorrhage: A Scoping Systematic Review
Published in
Frontiers in Neurology, August 2017
DOI 10.3389/fneur.2017.00379
Pubmed ID
Authors

Frederick A. Zeiler, Eric Peter Thelin, Marek Czosnyka, Peter J. Hutchinson, David K. Menon, Adel Helmy

Abstract

To perform two scoping systematic reviews of the literature on cytokine measurement in cerebral microdialysis (CMD) and cerebrospinal fluid (CSF) in aneurysmal subarachnoid hemorrhage (SAH) patients, aiming to summarize the evidence relating cytokine levels to pathophysiology, disease progression, and outcome. Two separate systematic reviews were conducted: one for CMD cytokines and the second for CSF cytokines. Articles from MEDLINE, BIOSIS, EMBASE, Global Health, Scopus, Cochrane Library (inception to October 2016), reference lists of relevant articles, and gray literature were searched. Two reviewers independently identified all manuscripts utilizing predefined inclusion/exclusion criteria. A two-tier filter of references was conducted. Patient demographic and study data were extracted to tables. There were 9 studies identified describing the analysis of cytokines via CMD in 246 aneurysmal SAH patients. Similarly, 20 studies were identified describing the analysis of CSF cytokines in 630 patients. The two scoping systematic reviews demonstrated the following: (1) limited literature available on CMD cytokine measurement in aneurysmal SAH with some preliminary data supporting feasibility of measurement and potential association between interleukin (IL)-6 and patient outcome. (2) Various CSF measured cytokines may be associated with patient outcome at 3-6 months, including IL-1ra, IL-6, IL-8, and tumor necrosis factor-alpha. (3) There is a small literature body supporting an association between acute/subacute CSF transforming growth factor levels and the development of chronic hydrocephalus at 2-3 months. The evaluation of CMD and CSF cytokines is an emerging area of the literature in aneurysmal SAH. Further large prospective multicenter studies on cytokines in CMD and CSF need to be conducted.

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Geographical breakdown

Country Count As %
Unknown 36 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 17%
Student > Bachelor 6 17%
Other 4 11%
Researcher 3 8%
Professor > Associate Professor 3 8%
Other 7 19%
Unknown 7 19%
Readers by discipline Count As %
Medicine and Dentistry 14 39%
Neuroscience 9 25%
Environmental Science 1 3%
Social Sciences 1 3%
Computer Science 1 3%
Other 2 6%
Unknown 8 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2017.
All research outputs
#17,910,703
of 22,996,001 outputs
Outputs from Frontiers in Neurology
#7,132
of 11,889 outputs
Outputs of similar age
#227,869
of 317,853 outputs
Outputs of similar age from Frontiers in Neurology
#118
of 198 outputs
Altmetric has tracked 22,996,001 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,889 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,853 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 198 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.