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Attention Score in Context
| Title |
Effects of Subthalamic and Nigral Stimulation on Gait Kinematics in Parkinson’s Disease
|
|---|---|
| Published in |
Frontiers in Neurology, October 2017
|
| DOI | 10.3389/fneur.2017.00543 |
| Pubmed ID | |
| Authors |
Marlieke Scholten, Johannes Klemt, Melanie Heilbronn, Christian Plewnia, Bastiaan R. Bloem, Friedemann Bunjes, Rejko Krüger, Alireza Gharabaghi, Daniel Weiss |
| Abstract |
Conventional subthalamic deep brain stimulation for Parkinson's disease (PD) presumably modulates the spatial component of gait. However, temporal dysregulation of gait is one of the factors that is tightly associated with freezing of gait (FOG). Temporal locomotor integration may be modulated differentially at distinct levels of the basal ganglia. Owing to its specific descending brainstem projections, stimulation of the substantia nigra pars reticulata (SNr) area might modulate spatial and temporal parameters of gait differentially compared to standard subthalamic nucleus (STN) stimulation. Here, we aimed to characterize the differential effect of STN or SNr stimulation on kinematic gait parameters. We analyzed biomechanical parameters during unconstrained over ground walking in 12 PD patients with subthalamic deep brain stimulation and FOG. Patients performed walking in three therapeutic conditions: (i) Off stimulation, (ii) STN stimulation (alone), and (iii) SNr stimulation (alone). SNr stimulation was achieved by stimulating the most caudal contact of the electrode. We recorded gait using three sensors (each containing a tri-axial accelerometer, gyroscope, and magnetometer) attached on both left and right ankle, and to the lumbar spine. STN stimulation improved both the spatial features (stride length, stride length variability) and the temporal parameters of gait. SNr stimulation improved temporal parameters of gait (swing time asymmetry). Correlation analysis suggested that patients with more medial localization of the SNr contact associated with a stronger regularization of gait. These results suggest that SNr stimulation might support temporal regularization of gait integration. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 86 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 15% |
| Student > Master | 12 | 14% |
| Researcher | 10 | 12% |
| Student > Bachelor | 9 | 10% |
| Student > Doctoral Student | 7 | 8% |
| Other | 9 | 10% |
| Unknown | 26 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 17 | 20% |
| Medicine and Dentistry | 15 | 17% |
| Engineering | 9 | 10% |
| Sports and Recreations | 3 | 3% |
| Psychology | 2 | 2% |
| Other | 8 | 9% |
| Unknown | 32 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2017.
All research outputs
#20,450,513
of 23,006,268 outputs
Outputs from Frontiers in Neurology
#8,927
of 11,904 outputs
Outputs of similar age
#284,777
of 326,542 outputs
Outputs of similar age from Frontiers in Neurology
#146
of 188 outputs
Altmetric has tracked 23,006,268 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,904 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 188 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.