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Estrogen-Dependent Changes in Dura Mater Microvasculature Add New Insights to the Pathogenesis of Headache

Overview of attention for article published in Frontiers in Neurology, October 2017
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  • Above-average Attention Score compared to outputs of the same age and source (59th percentile)

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Title
Estrogen-Dependent Changes in Dura Mater Microvasculature Add New Insights to the Pathogenesis of Headache
Published in
Frontiers in Neurology, October 2017
DOI 10.3389/fneur.2017.00549
Pubmed ID
Authors

Olga V. Glinskii, Virginia H. Huxley, Vladislav V. Glinsky

Abstract

The pathogenesis of headaches is a matter of ongoing discussion of two major theories describing it either as a vascular phenomenon resulting from vasodilation or primarily as a neurogenic process accompanied by secondary vasodilation associated with sterile neurogenic inflammation. While summarizing current views on neurogenic and vascular origins of headache, this mini review adds new insights regarding how smooth muscle-free microvascular networks, discovered within dura mater connective tissue stroma (previously thought to be "avascular"), may become a site of initial insult generating the background for the development of headache. Deficiencies in estrogen-dependent control of microvascular integrity leading to plasma protein extravasation, potential activation of perivascular and connective tissue stroma nociceptive neurons, and triggering of inflammatory responses are described. Finally, possible avenues for controlling and preventing these pathophysiological changes are discussed.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 23%
Student > Bachelor 2 15%
Professor 1 8%
Student > Ph. D. Student 1 8%
Professor > Associate Professor 1 8%
Other 0 0%
Unknown 5 38%
Readers by discipline Count As %
Neuroscience 3 23%
Biochemistry, Genetics and Molecular Biology 2 15%
Unspecified 1 8%
Nursing and Health Professions 1 8%
Medicine and Dentistry 1 8%
Other 0 0%
Unknown 5 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2023.
All research outputs
#13,627,245
of 23,504,694 outputs
Outputs from Frontiers in Neurology
#5,230
of 12,428 outputs
Outputs of similar age
#161,818
of 328,126 outputs
Outputs of similar age from Frontiers in Neurology
#73
of 188 outputs
Altmetric has tracked 23,504,694 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 12,428 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.4. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,126 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 188 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.