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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Tau Protein in Oral Mucosa and Cognitive State: A Cross-sectional Study
|
|---|---|
| Published in |
Frontiers in Neurology, October 2017
|
| DOI | 10.3389/fneur.2017.00554 |
| Pubmed ID | |
| Authors |
Luis Fernando Arredondo, Saray Aranda-Romo, Ildefonso Rodríguez-Leyva, Erika Chi-Ahumada, Sami K. Saikaly, Diana P. Portales-Pérez, Roberto González-Amaro, Mariana Salgado-Bustamante, Lourdes Enriquez-Macias, William Eng, Robert A. Norman, Maria E. Jimenez-Capdeville |
| Abstract |
Neurodegenerative diseases are characterized by the presence of abnormal aggregates of proteins in brain tissue. Among them, the presence of aggregates of phosphorylated Tau protein (p-Tau) is the hallmark of Alzheimer's disease (AD) and other major neurodegenerative disorders such as corticobasal degeneration and frontotemporal dementia among others. Although Tau protein has previously been assumed to be exclusive to the central nervous system, it is also found in peripheral tissues. The purpose of this study was to determine whether there is a differential Tau expression in oral mucosa cells according to cognitive impairment. Eighty-one subjects were enrolled in the study and classified per Mini-Mental State Examination test score into control, mild cognitive impairment (MCI), and severe cognitive impairment (SCI) groups. Immunocytochemistry and immunofluorescence revealed the presence of Tau and four p-Tau forms in the cytoplasm and nucleus of oral mucosa cells. More positivity was present in subjects with cognitive impairment than in control subjects, both in the nucleus and cytoplasm, in a speckle pattern. The mRNA expression of Tau by quantitative real-time polymerase chain reaction was higher in SCI as compared with the control group (P < 0.01). A significantly higher percentage of immunopositive cells in the SCI group was found via flow cytometry in comparison to controls and the MCI group (P < 0.01). These findings demonstrate the higher presence of p-Tau and Tau transcript in the oral mucosa of cognitively impaired subjects when compared with healthy subjects. The feasibility of p-Tau quantification by flow cytometry supports the prospective analysis of oral mucosa as a support tool for screening of proteinopathies in cognitively impaired patients. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 34 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 15% |
| Student > Master | 3 | 9% |
| Student > Postgraduate | 2 | 6% |
| Professor | 2 | 6% |
| Student > Doctoral Student | 1 | 3% |
| Other | 6 | 18% |
| Unknown | 15 | 44% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 4 | 12% |
| Biochemistry, Genetics and Molecular Biology | 2 | 6% |
| Neuroscience | 2 | 6% |
| Nursing and Health Professions | 2 | 6% |
| Social Sciences | 2 | 6% |
| Other | 6 | 18% |
| Unknown | 16 | 47% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 October 2017.
All research outputs
#20,449,496
of 23,005,189 outputs
Outputs from Frontiers in Neurology
#8,927
of 11,904 outputs
Outputs of similar age
#284,316
of 325,897 outputs
Outputs of similar age from Frontiers in Neurology
#143
of 188 outputs
Altmetric has tracked 23,005,189 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,904 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 188 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.