Title |
Systemic and Local Cytokine Profile following Spinal Cord Injury in Rats: A Multiplex Analysis
|
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Published in |
Frontiers in Neurology, October 2017
|
DOI | 10.3389/fneur.2017.00581 |
Pubmed ID | |
Authors |
Yana O. Mukhamedshina, Elvira R. Akhmetzyanova, Ekaterina V. Martynova, Svetlana F. Khaiboullina, Luisa R. Galieva, Albert A. Rizvanov |
Abstract |
Our study of the changes in cytokine profile in blood serum and in the spinal cord after traumatic spinal cord injury (SCI) has shown that an inflammatory reaction and immunological response are not limited to the CNS, but widespread. This fact was confirmed by changes detected in a cytokine profile in blood serum samples [MIP-1α, interleukin 1 (IL-1) α, IL-2, IL-5, IL-1β, MCP-1, RANTES]. There were also changes in the levels of MIP-1α, IL-1α, IL-2, IL-5, IL-18, GM-colony-stimulating factor, IL-17α, IFN-γ, IL-10, IL-13, MCP-1, and GRO KC CINC-1 in samples of the rat injured spinal cord. The results underscore the complex cytokine network imbalance exhibited after SCI and show significant changes in the concentrations of 14 cytokines/chemokines with different inflammatory and immunological activities. |
X Demographics
Geographical breakdown
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Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 58 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 14 | 24% |
Researcher | 8 | 14% |
Student > Bachelor | 7 | 12% |
Student > Master | 5 | 9% |
Student > Doctoral Student | 3 | 5% |
Other | 7 | 12% |
Unknown | 14 | 24% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Social Sciences | 2 | 3% |
Other | 5 | 9% |
Unknown | 15 | 26% |