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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Patterns of Retinal Ganglion Cell Damage in Neurodegenerative Disorders: Parvocellular vs Magnocellular Degeneration in Optical Coherence Tomography Studies
|
|---|---|
| Published in |
Frontiers in Neurology, December 2017
|
| DOI | 10.3389/fneur.2017.00710 |
| Pubmed ID | |
| Authors |
Chiara La Morgia, Lidia Di Vito, Valerio Carelli, Michele Carbonelli |
| Abstract |
Many neurodegenerative disorders, such as Parkinson's disease (PD) and Alzheimer's disease (AD), are characterized by loss of retinal ganglion cells (RGCs) as part of the neurodegenerative process. Optical coherence tomography (OCT) studies demonstrated variable degree of optic atrophy in these diseases. However, the pattern of degenerative changes affecting the optic nerve (ON) can be different. In particular, neurodegeneration is more evident for magnocellular RGCs in AD and multiple system atrophy with a pattern resembling glaucoma. Conversely, in PD and Huntington's disease, the parvocellular RGCs are more vulnerable. This latter pattern closely resembles that of mitochondrial optic neuropathies, possibly pointing to similar pathogenic mechanisms. In this review, the currently available evidences on OCT findings in these neurodegenerative disorders are summarized with particular emphasis on the different pattern of RGC loss. The ON degeneration could become a validated biomarker of the disease, which may turn useful to follow natural history and possibly assess therapeutic efficacy. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 20% |
| United States | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 126 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 12% |
| Student > Bachelor | 15 | 12% |
| Student > Master | 12 | 10% |
| Professor | 10 | 8% |
| Other | 9 | 7% |
| Other | 26 | 21% |
| Unknown | 39 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 32 | 25% |
| Neuroscience | 25 | 20% |
| Biochemistry, Genetics and Molecular Biology | 6 | 5% |
| Computer Science | 3 | 2% |
| Nursing and Health Professions | 2 | 2% |
| Other | 15 | 12% |
| Unknown | 43 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 December 2019.
All research outputs
#7,542,364
of 23,011,300 outputs
Outputs from Frontiers in Neurology
#4,684
of 11,905 outputs
Outputs of similar age
#152,895
of 440,911 outputs
Outputs of similar age from Frontiers in Neurology
#64
of 206 outputs
Altmetric has tracked 23,011,300 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,905 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 440,911 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 206 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.