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Elevated Serum α-Synuclein Autoantibodies in Patients with Parkinson’s Disease Relative to Alzheimer’s Disease and Controls

Overview of attention for article published in Frontiers in Neurology, December 2017
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  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

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Title
Elevated Serum α-Synuclein Autoantibodies in Patients with Parkinson’s Disease Relative to Alzheimer’s Disease and Controls
Published in
Frontiers in Neurology, December 2017
DOI 10.3389/fneur.2017.00720
Pubmed ID
Authors

Ali Shalash, Mohamed Salama, Marianne Makar, Tamer Roushdy, Hanan Hany Elrassas, Wael Mohamed, Mahmoud El-Balkimy, Mohamed Abou Donia

Abstract

Early diagnosis of neurodegenerative diseases is of paramount importance for successful treatment. Lack of sensitive and early biomarkers for diagnosis of diseases like Parkinson's disease (PD) is a handicapping problem for all movement disorders specialists. Using serum autoimmune antibodies (AIAs) against neural proteins is a new promising strategy to diagnose brain disorders through non-invasive and cost-effective method. In the present study, we measured the level of AIAs against α-synuclein (α-syn), which is an important protein involved in the pathogenesis of PD. In our study patients with PD (46 patients), Alzheimer's disease (AD) (27 patients) and healthy controls (20 patients) were evaluated according to their sera α-syn AIAs levels. Interestingly, α-syn AIAs were significantly elevated in PD group compared to AD and healthy controls, which advocates their use for diagnosis of PD.

X Demographics

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The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 63 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 16%
Student > Ph. D. Student 9 14%
Researcher 9 14%
Student > Master 7 11%
Other 2 3%
Other 7 11%
Unknown 19 30%
Readers by discipline Count As %
Neuroscience 13 21%
Medicine and Dentistry 9 14%
Biochemistry, Genetics and Molecular Biology 6 10%
Nursing and Health Professions 2 3%
Agricultural and Biological Sciences 2 3%
Other 7 11%
Unknown 24 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2018.
All research outputs
#14,086,689
of 23,011,300 outputs
Outputs from Frontiers in Neurology
#5,513
of 11,905 outputs
Outputs of similar age
#231,386
of 440,922 outputs
Outputs of similar age from Frontiers in Neurology
#81
of 206 outputs
Altmetric has tracked 23,011,300 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,905 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 440,922 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 206 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.