Title |
Romiplostim for the Emergency Management of Severe Immune Thrombocytopenia with Intracerebral Hemorrhage
|
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Published in |
Frontiers in Neurology, January 2018
|
DOI | 10.3389/fneur.2017.00737 |
Pubmed ID | |
Authors |
Romain Gellens, Sabrina Habchi, Sebastien Freppel, David Couret, Silvia Iacobelli |
Abstract |
Currently, we lack well-established guidelines for the emergency management of severe immune thrombocytopenia (ITP) with life-threatening bleeding. We now report the management of two patients with severe ITP, complicated by substantial cerebral hemorrhage, requiring urgent surgery due to refractory intracranial hypertension. To rapidly boost platelet counts (PCs), corticosteroids, intravenous immunoglobulin, and iterative platelet transfusions were given; all were ineffectual. Romiplostim, a thrombopoietin receptor agonist, was then administered as an "on demand therapy," with the result that a rapid and sustained increase of PCs was achieved, thus allowing for postoperative hemostasis. Both patients recovered good neurological condition, suggesting the potential utility of romiplostim, in combined therapy, for the emergency management of severe ITP. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 42 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 5 | 12% |
Student > Doctoral Student | 5 | 12% |
Researcher | 5 | 12% |
Student > Bachelor | 5 | 12% |
Student > Master | 3 | 7% |
Other | 3 | 7% |
Unknown | 16 | 38% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 13 | 31% |
Nursing and Health Professions | 5 | 12% |
Social Sciences | 2 | 5% |
Biochemistry, Genetics and Molecular Biology | 1 | 2% |
Agricultural and Biological Sciences | 1 | 2% |
Other | 4 | 10% |
Unknown | 16 | 38% |