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Cerebral Ischemia Increases Small Ubiquitin-Like Modifier Conjugation within Human Penumbral Tissue: Radiological–Pathological Correlation

Overview of attention for article published in Frontiers in Neurology, January 2018
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Title
Cerebral Ischemia Increases Small Ubiquitin-Like Modifier Conjugation within Human Penumbral Tissue: Radiological–Pathological Correlation
Published in
Frontiers in Neurology, January 2018
DOI 10.3389/fneur.2017.00738
Pubmed ID
Authors

Joshua D. Bernstock, Daniel G. Ye, Allison Griffin, Yang-ja Lee, John Lynch, Lawrence L. Latour, Gregory K. Friedman, Dragan Maric, John M. Hallenbeck

Abstract

Posttranslational modification by small ubiquitin-like modifier (SUMO) regulates myriad physiological processes within cells and has been demonstrated to be highly activated in murine brains after cerebral ischemia. Numerous in vitro and murine in vivo studies have demonstrated that this increased SUMO conjugation is an endogenous neuroprotective stress response that has potential in being leveraged to develop novel therapies for ischemic stroke. However, SUMO activation has not yet been studied in poststroke human brains, presenting a clear limitation in translating experimental successes in murine models to human patients. Accordingly, here, we present a case wherein the brain tissue of a stroke patient (procured shortly after death) was processed by multiplex immunohistochemistry to investigate SUMO activation.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 21%
Other 2 14%
Student > Doctoral Student 1 7%
Student > Master 1 7%
Student > Bachelor 1 7%
Other 0 0%
Unknown 6 43%
Readers by discipline Count As %
Neuroscience 5 36%
Veterinary Science and Veterinary Medicine 1 7%
Agricultural and Biological Sciences 1 7%
Chemistry 1 7%
Unknown 6 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 January 2018.
All research outputs
#15,488,947
of 23,016,919 outputs
Outputs from Frontiers in Neurology
#6,842
of 11,913 outputs
Outputs of similar age
#270,779
of 443,072 outputs
Outputs of similar age from Frontiers in Neurology
#112
of 211 outputs
Altmetric has tracked 23,016,919 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,913 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 443,072 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 211 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.