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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Microglia and CNS Interleukin-1: Beyond Immunological Concepts
|
|---|---|
| Published in |
Frontiers in Neurology, January 2018
|
| DOI | 10.3389/fneur.2018.00008 |
| Pubmed ID | |
| Authors |
Xiaoyu Liu, Ning Quan |
| Abstract |
Activation of microglia and expression of the inflammatory cytokine interleukin-1 (IL-1) in the CNS have become almost synonymous with neuroinflammation. In numerous studies, increased CNS IL-1 expression and altered microglial morphology have been used as hallmarks of CNS inflammation. A central concept of how CNS IL-1 and microglia influence functions of the nervous system was derived from the notion initially generated in the peripheral immune system: IL-1 stimulates monocyte/macrophage (the peripheral counterparts of microglia) to amplify inflammation. It is increasingly clear, however, CNS IL-1 acts on other targets in the CNS and microglia participates in many neural functions that are not related to immunological activities. Further, CNS exhibits immunological privilege (although not as absolute as previously thought), rendering amplification of inflammation within CNS under stringent control. This review will analyze current literature to evaluate the contribution of immunological and non-immunological aspects of microglia/IL-1 interaction in the CNS to gain insights for how these aspects might affect health and disease in the nervous tissue. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 236 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 236 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 52 | 22% |
| Student > Bachelor | 36 | 15% |
| Student > Master | 29 | 12% |
| Researcher | 22 | 9% |
| Student > Doctoral Student | 12 | 5% |
| Other | 28 | 12% |
| Unknown | 57 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 50 | 21% |
| Biochemistry, Genetics and Molecular Biology | 33 | 14% |
| Medicine and Dentistry | 27 | 11% |
| Agricultural and Biological Sciences | 24 | 10% |
| Immunology and Microbiology | 11 | 5% |
| Other | 22 | 9% |
| Unknown | 69 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2018.
All research outputs
#20,461,148
of 23,018,998 outputs
Outputs from Frontiers in Neurology
#8,932
of 11,914 outputs
Outputs of similar age
#378,143
of 441,019 outputs
Outputs of similar age from Frontiers in Neurology
#158
of 223 outputs
Altmetric has tracked 23,018,998 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,914 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 441,019 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 223 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.