Title |
Efficacy of Modified Atkins Ketogenic Diet in Chronic Cluster Headache: An Open-Label, Single-Arm, Clinical Trial
|
---|---|
Published in |
Frontiers in Neurology, February 2018
|
DOI | 10.3389/fneur.2018.00064 |
Pubmed ID | |
Authors |
Cherubino Di Lorenzo, Gianluca Coppola, Davide Di Lenola, Maurizio Evangelista, Giulio Sirianni, Paolo Rossi, Giorgio Di Lorenzo, Mariano Serrao, Francesco Pierelli |
Abstract |
Drug-resistant cluster headache (CH) is still an open clinical challenge. Recently, our group observed the clinical efficacy of a ketogenic diet (KD), usually adopted to treat drug-resistant epilepsies, on migraine. Here, we aim to detect the effect of KD in a group of drug-resistant chronic CH (CCH) patients. Eighteen drug-resistant CCH patients underwent a 12-week KD (Modified Atkins Diet, MAD), and the clinical response was evaluated in terms of response (≥50% attack reduction). Of the 18 CCH patients, 15 were considered responders to the diet (11 experienced a full resolution of headache, and 4 had a headache reduction of at least 50% in terms of mean monthly number of attacks during the diet). The mean monthly number of attacks for each patient at the baseline was 108.71 (SD = 81.71); at the end of the third month of diet, it was reduced to 31.44 (SD = 84.61). We observed for the first time that a 3-month ketogenesis ameliorates clinical features of CCH. www.ClinicalTrials.gov, identifier NCT03244735. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 21 | 30% |
United Kingdom | 9 | 13% |
South Africa | 2 | 3% |
Italy | 2 | 3% |
New Zealand | 2 | 3% |
Brazil | 2 | 3% |
Germany | 2 | 3% |
Belgium | 1 | 1% |
Armenia | 1 | 1% |
Other | 4 | 6% |
Unknown | 24 | 34% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 47 | 67% |
Practitioners (doctors, other healthcare professionals) | 18 | 26% |
Scientists | 4 | 6% |
Unknown | 1 | 1% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 65 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 9 | 14% |
Student > Bachelor | 8 | 12% |
Other | 7 | 11% |
Researcher | 7 | 11% |
Student > Doctoral Student | 5 | 8% |
Other | 8 | 12% |
Unknown | 21 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 26% |
Neuroscience | 5 | 8% |
Nursing and Health Professions | 4 | 6% |
Agricultural and Biological Sciences | 4 | 6% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Other | 3 | 5% |
Unknown | 29 | 45% |