Title |
Impact of the Thrombectomy Trials on the Management and Outcome of Large Vessel Stroke: Data From the Lyon Stroke Center
|
---|---|
Published in |
Frontiers in Neurology, August 2018
|
DOI | 10.3389/fneur.2018.00722 |
Pubmed ID | |
Authors |
Louis Viannay, Julie Haesebaert, Fannie Florin, Roberto Riva, Laura Mechtouff, Benjamin Gory, Elodie Ong, Paul-Emile Labeyrie, Laurent Derex, Marc Hermier, Leila Chamard, Lise-Prune Berner, Roxana Ameli, Yves Berthezène, Francis Turjman, Norbert Nighoghossian, Tae-Hee Cho |
Abstract |
Introduction: Randomized trials (RT) have recently validated the superiority of thrombectomy over standard medical care, including intravenous thrombolysis (IVT). However, data on their impact on routine clinical care remains scarce. Methods: Using a prospective observational registry, we assessed: (1) the clinical and radiological characteristics of all consecutive patients treated with thrombectomy; (2) the outcome of all patients with M1 occlusion (treated with thrombectomy or IVT alone). Two periods were compared: before (2013-2014) and after (2015-2016) the publication of RT. Results: Endovascular procedures significantly increased between the two periods (N = 82 vs. 314, p < 0.0001). In 2015-2016, patients were older (median [IQR]: 69 [57-80]; vs. 66 [53-74]; p = 0.008), had shorter door-to-clot times (69 [47-95]; vs. 110 [83-155]; p < 0.0001) resulting in a trend toward shorter delay from symptom onset to reperfusion (232 [185-300]; vs. 250 [200-339]; p = 0.1), with higher rates of reperfusion (71 vs. 48%; p = 0.0001). Conversely, no significant differences in baseline NIHSS scores, ASPECTS, delay to IVT or intracranial hemorrhage were found. In 2015-2016, patients with M1 occlusion were treated with thrombectomy more often than in 2013-2014 (87 vs. 32%, respectively; p < 0.0001), with a significant improvement in clinical outcome (shift analysis, lower modified Rankin scale scores: OR = 1.68; 95% CI: 1.10-2.57; p = 0.017). Conclusion: Following the publication of RT, thrombectomy was rapidly implemented with significant improvements in intrahospital delay and reperfusion rates. Treatment with thrombectomy increased with better clinical outcomes in patients with M1 occlusion. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 33% |
France | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 27 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 4 | 15% |
Student > Bachelor | 4 | 15% |
Other | 3 | 11% |
Student > Ph. D. Student | 2 | 7% |
Researcher | 2 | 7% |
Other | 2 | 7% |
Unknown | 10 | 37% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 33% |
Biochemistry, Genetics and Molecular Biology | 1 | 4% |
Arts and Humanities | 1 | 4% |
Social Sciences | 1 | 4% |
Agricultural and Biological Sciences | 1 | 4% |
Other | 0 | 0% |
Unknown | 14 | 52% |