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Improving Prefrontal Cortex Function in Schizophrenia Through Focused Training of Cognitive Control

Overview of attention for article published in Frontiers in Human Neuroscience, January 2010
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Title
Improving Prefrontal Cortex Function in Schizophrenia Through Focused Training of Cognitive Control
Published in
Frontiers in Human Neuroscience, January 2010
DOI 10.3389/fnhum.2010.00032
Pubmed ID
Authors

Bethany G. Edwards, Deanna M. Barch, Todd S. Braver

Abstract

Previous research has shown that individuals with schizophrenia show deficits in cognitive control functions thought to depend on the lateral prefrontal cortex (PFC), and its interactions with related regions. The current study explored the effects of instructed strategy training on improving cognitive control functioning in patients with schizophrenia. Event-related fMRI was used to test whether effects of such training were associated with changes in brain activity dynamics during task performance. Patients with schizophrenia (N = 22) performed the AX-CPT cognitive control task in two-sessions, with the first occurring pre-training and second following strategy training. The training protocol emphasized direct encoding of contextual cues and updating response selection goals in accordance with cue information. A matched group of healthy controls (N = 14) underwent the same protocol but were only scanned in the pre-training session. In the pre-training session, patients exhibited behavioral evidence of impaired utilization of contextual cue information, along with reduced cue-related activity - but increased activation during probe and response periods - in a network of regions associated with cognitive control, centered on the lateral PFC. Following training, this pattern of activation dynamics significantly shifted, normalizing towards the pattern observed in controls. These activation effects were associated with both clinical symptoms and behavioral performance improvements. The results suggest that focused strategy training may facilitate cognitive task performance in patients with schizophrenia by changing the dynamics of activity within critical control-related brain regions.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 193 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 2%
United Kingdom 3 2%
Australia 1 <1%
Canada 1 <1%
Germany 1 <1%
Spain 1 <1%
Argentina 1 <1%
Greece 1 <1%
Japan 1 <1%
Other 0 0%
Unknown 179 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 41 21%
Researcher 35 18%
Student > Master 26 13%
Student > Doctoral Student 20 10%
Professor 13 7%
Other 33 17%
Unknown 25 13%
Readers by discipline Count As %
Psychology 91 47%
Medicine and Dentistry 20 10%
Neuroscience 17 9%
Agricultural and Biological Sciences 14 7%
Engineering 8 4%
Other 4 2%
Unknown 39 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2010.
All research outputs
#20,165,369
of 22,675,759 outputs
Outputs from Frontiers in Human Neuroscience
#6,513
of 7,115 outputs
Outputs of similar age
#156,591
of 163,537 outputs
Outputs of similar age from Frontiers in Human Neuroscience
#62
of 68 outputs
Altmetric has tracked 22,675,759 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,115 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,537 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.