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Attention Score in Context
| Title |
A Potential Role for a Genetic Variation of AKAP5 in Human Aggression and Anger Control
|
|---|---|
| Published in |
Frontiers in Human Neuroscience, January 2011
|
| DOI | 10.3389/fnhum.2011.00175 |
| Pubmed ID | |
| Authors |
Sylvia Richter, Xenia Gorny, Josep Marco-Pallares, Ulrike M. Krämer, Judith Machts, Adriana Barman, Hans-Gert Bernstein, Rebecca Schüle, Ludger Schöls, Antoni Rodriguez-Fornells, Carsten Reissner, Torsten Wüstenberg, Hans-Jochen Heinze, Eckart D. Gundelfinger, Emrah Düzel, Thomas F. Münte, Constanze I. Seidenbecher, Björn H. Schott |
| Abstract |
The A-kinase-anchoring protein 5 (AKAP5), a post-synaptic multi-adaptor molecule that binds G-protein-coupled receptors and intracellular signaling molecules has been implicated in emotional processing in rodents, but its role in human emotion and behavior is up to now still not quite clear. Here, we report an association of individual differences in aggressive behavior and anger expression with a functional genetic polymorphism (Pro100Leu) in the human AKAP5 gene. Among a cohort of 527 young, healthy individuals, carriers of the less common Leu allele (15.6% allele frequency) scored significantly lower in the physical aggression domain of the Buss and Perry Aggression Questionnaire and higher in the anger control dimension of the state-trait anger expression inventory. In a functional magnetic resonance imaging experiment we could further demonstrate that AKAP5 Pro100Leu modulates the interaction of negative emotional processing and executive functions. In order to investigate implicit processes of anger control, we used the well-known flanker task to evoke processes of action monitoring and error processing and added task-irrelevant neutral or angry faces in the background of the flanker stimuli. In line with our predictions, Leu carriers showed increased activation of the anterior cingulate cortex (ACC) during emotional interference, which in turn predicted shorter reaction times and might be related to stronger control of emotional interference. Conversely, Pro homozygotes exhibited increased orbitofrontal cortex (OFC) activation during emotional interference, with no behavioral advantage. Immunohistochemistry revealed AKAP5 expression in post mortem human ACC and OFC. Our results suggest that AKAP5 Pro100Leu contributes to individual differences in human aggression and anger control. Further research is warranted to explore the detailed role of AKAP5 and its gene product in human emotion processing. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Switzerland | 1 | 2% |
| Unknown | 58 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 22% |
| Student > Master | 8 | 13% |
| Professor | 6 | 10% |
| Researcher | 6 | 10% |
| Student > Bachelor | 5 | 8% |
| Other | 11 | 18% |
| Unknown | 11 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 25 | 42% |
| Neuroscience | 9 | 15% |
| Agricultural and Biological Sciences | 5 | 8% |
| Medicine and Dentistry | 3 | 5% |
| Computer Science | 1 | 2% |
| Other | 4 | 7% |
| Unknown | 13 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2021.
All research outputs
#13,147,386
of 22,699,621 outputs
Outputs from Frontiers in Human Neuroscience
#3,842
of 7,125 outputs
Outputs of similar age
#132,539
of 180,390 outputs
Outputs of similar age from Frontiers in Human Neuroscience
#61
of 118 outputs
Altmetric has tracked 22,699,621 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,125 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.5. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 180,390 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 118 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.