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Dynamic Functional Reorganizations and Relationship with Working Memory Performance in Healthy Aging

Overview of attention for article published in Frontiers in Human Neuroscience, January 2012
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Title
Dynamic Functional Reorganizations and Relationship with Working Memory Performance in Healthy Aging
Published in
Frontiers in Human Neuroscience, January 2012
DOI 10.3389/fnhum.2012.00152
Pubmed ID
Authors

Roser Sala-Llonch, Eider M. Arenaza-Urquijo, Cinta Valls-Pedret, Dídac Vidal-Piñeiro, Nuria Bargalló, Carme Junqué, David Bartrés-Faz

Abstract

In recent years, several theories have been proposed in attempts to identify the neural mechanisms underlying successful cognitive aging. Old subjects show increased neural activity during the performance of tasks, mainly in prefrontal areas, which is interpreted as a compensatory mechanism linked to functional brain efficiency. Moreover, resting-state studies have concluded that elders show disconnection or disruption of large-scale functional networks. We used functional MRI during resting-state and a verbal n-back task with different levels of memory load in a cohort of young and old healthy adults to identify patterns of networks associated with working memory and brain default mode. We found that the disruption of resting-state networks in the elderly coexists with task-related overactivations of certain brain areas and with reorganizations within these functional networks. Moreover, elders who were able to activate additional areas and to recruit a more bilateral frontal pattern within the task-related network achieved successful performance on the task. We concluded that the balanced and plastic reorganization of brain networks underlies successful cognitive aging. This observation allows the integration of several theories that have been proposed to date regarding the aging brain.

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 115 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 3 3%
United States 2 2%
Sweden 1 <1%
China 1 <1%
United Kingdom 1 <1%
Japan 1 <1%
Singapore 1 <1%
Unknown 105 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 23%
Researcher 24 21%
Student > Master 18 16%
Student > Doctoral Student 6 5%
Student > Postgraduate 5 4%
Other 15 13%
Unknown 20 17%
Readers by discipline Count As %
Psychology 30 26%
Neuroscience 23 20%
Medicine and Dentistry 12 10%
Agricultural and Biological Sciences 3 3%
Nursing and Health Professions 2 2%
Other 15 13%
Unknown 30 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2014.
All research outputs
#14,781,203
of 22,756,196 outputs
Outputs from Frontiers in Human Neuroscience
#4,907
of 7,138 outputs
Outputs of similar age
#159,429
of 244,272 outputs
Outputs of similar age from Frontiers in Human Neuroscience
#208
of 294 outputs
Altmetric has tracked 22,756,196 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,138 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.5. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,272 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 294 others from the same source and published within six weeks on either side of this one. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.